ArticleThe Journal of physiology2013
Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 35 citations in OpenAlex.
- Loss of the endoplasmic reticulum protein canopy 1 disrupts the function and circuit organization of V2R-expressing vomeronasal sensory neurons.Development (Cambridge, England) · 2026Article
- Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the accessory olfactory bulb and medial amygdala.The Journal of comparative neurology · 2024Article
- Contactin-6-deficient male mice exhibit the abnormal function of the accessory olfactory system and impaired reproductive behavior.Brain and behavior · 2023Article
- Article
- Behavioral and Physiologic Effects of Dirty Bedding Exposure in Female ICR Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Regulation of habenular G-protein gamma 8 on learning and memory via modulation of the central acetylcholine system.Molecular psychiatry · 2021Article
- Mechanisms underlying pre- and postnatal development of the vomeronasal organ.Cellular and molecular life sciences : CMLS · 2021Review
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Smad4-dependent morphogenic signals control the maturation and axonal targeting of basal vomeronasal sensory neurons to the accessory olfactory bulb.Development (Cambridge, England) · 2020Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- G protein γ subunit Gγ13 is essential for olfactory function and aggressive behavior in mice.Neuroreport · 2018Article
- Identification of Genes Enriched in GnRH Neurons by Translating Ribosome Affinity Purification and RNAseq in Mice.Endocrinology · 2018Article
- Adult neural stem cell dysfunction in the subventricular zone of the lateral ventricle leads to diabetic olfactory defects.Neural regeneration research · 2017Article
- Neural map formation and sensory coding in the vomeronasal system.Cellular and molecular life sciences : CMLS · 2015Review
- Mammalian pheromones: emerging properties and mechanisms of detection.Current opinion in neurobiology · 2015Review
- A wide range of pheromone-stimulated sexual and reproductive behaviors in female mice depend on G protein Gαo.BMC biology · 2014Article
- Signaling mechanisms and behavioral function of the mouse basal vomeronasal neuroepithelium.Frontiers in neuroanatomy · 2014Review
- Lacrimal gland removal impairs sexual behavior in mice.Frontiers in neuroanatomy · 2014Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterotrimeric G-proteins are critical players in the transduction mechanisms underlying odorant and pheromonal signalling. In the vomeronasal organ (VNO) of the adult mouse, two different G-protein complexes have been identified. Gαoβ2γ8 is preferentially expressed in the basal neurons and coexpresses with type-2 vomeronasal pheromone receptors (V2Rs) whereas Gαi2β2γ2 is found in the apical neurons and coexpresses with type-1 vomeronasal pheromone receptors (V1Rs). V2R-expressing neurons project to the posterior accessory olfactory bulb (AOB) whereas neurons expressing V1Rs send their axon to the anterior AOB. Gγ8 is also expressed in developing olfactory neurons where this protein is probably associated with Go. Here, we generated mice with a targeted deletion of the Gγ8 gene and investigated the behavioural effects and the physiological consequences of this mutation. Gγ8(-/-) mice show a normal development of the main olfactory epithelium; moreover, they do not display major deficits in odour perception. In contrast, the VNO undergoes a slow but remarkable loss of basal neurons starting from the fourth postnatal week, with a 40% reduction of cells at 2 months and 70% at 1 year. This loss is associated with a reduced early-gene expression in the posterior AOB of mice stimulated with pheromones. More interestingly, the Gγ8 deletion specifically leads to a reduced pheromone-mediated aggressiveness in both males and females, all other socio-sexual behaviours remaining unaltered. This study defines a specific role for Gγ8 in maintenance of the neuronal population of the VNO and in the mechanisms of pheromonal signalling that involve the aggressive behaviour towards conspecifics.
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