ArticleProceedings of the National Academy of Sciences of the United States of America2013
Transducin translocation contributes to rod survival and enhances synaptic transmission from rods to rod bipolar cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- The physiology of dark adaptation: Progress and future directions.Progress in retinal and eye research · 2025Review
- Microglial depletion decreases Müller cell maturation and inner retinal vascular density.Cell communication and signaling : CCS · 2025Article
- Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex.Frontiers in molecular neuroscience · 2024Article
- Reconstitution of the phosphodiesterase 6 maturation process important for photoreceptor cell function.The Journal of biological chemistry · 2024Article
- Article
- A Novel Role for UNC119 as an Enhancer of Synaptic Transmission.International journal of molecular sciences · 2023Article
- Article
- Solo vs. Chorus: Monomers and Oligomers of Arrestin Proteins.International journal of molecular sciences · 2022Review
- Light responses of mammalian cones.Pflugers Archiv : European journal of physiology · 2021Review
- Analysis of waveform and amplitude of mouse rod and cone flash responses.The Journal of physiology · 2021Article
- Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling.Cell systems · 2021Article
- Rod Photoreceptors Avoid Saturation in Bright Light by the Movement of the G Protein Transducin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Arginylation Regulates G-protein Signaling in the Retina.Frontiers in cell and developmental biology · 2021Article
- Retbindin: A riboflavin Binding Protein, Is Critical for Photoreceptor Homeostasis and Survival in Models of Retinal Degeneration.International journal of molecular sciences · 2020Article
- Rhodopsin-mediated light-off-induced protein kinase A activation in mouse rod photoreceptor cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Dark noise and retinal degeneration from D190N-rhodopsin.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Synaptic ribbons foster active zone stability and illumination-dependent active zone enrichment of RIM2 and Cav1.4 in photoreceptor synapses.Scientific reports · 2020Article
- Transducin Partners Outside the Phototransduction Pathway.Frontiers in cellular neuroscience · 2020Article
- A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision.Frontiers in cellular neuroscience · 2020Review
- Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.The EMBO journal · 2019Article
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Authors and funding
8 authors.
Funding
Abstract
In rod photoreceptors, several phototransduction components display light-dependent translocation between cellular compartments. Notably, the G protein transducin translocates from rod outer segments to inner segments/spherules in bright light, but the functional consequences of translocation remain unclear. We generated transgenic mice where light-induced transducin translocation is impaired. These mice exhibited slow photoreceptor degeneration, which was prevented if they were dark-reared. Physiological recordings showed that control and transgenic rods and rod bipolar cells displayed similar sensitivity in darkness. After bright light exposure, control rods were more strongly desensitized than transgenic rods. However, in rod bipolar cells, this effect was reversed; transgenic rod bipolar cells were more strongly desensitized than control. This sensitivity reversal indicates that transducin translocation in rods enhances signaling to rod bipolar cells. The enhancement could not be explained by modulation of inner segment conductances or the voltage sensitivity of the synaptic Ca(2+) current, suggesting interactions of transducin with the synaptic machinery.
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