Evidence map›Paper›PMID 23836576›Full record

ArticleThe American journal of tropical medicine and hygiene2013

Serum levels of neopterin during antimicrobial treatment for Mycobacterium ulcerans infection.

Janine de Zeeuw, Sridevi Duggirala, Willemien A Nienhuis, K Mohammed Abass, Wilson Tuah, Till F Omansen, Tjip S van der Werf, Ymkje Stienstra

Abstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Janine de ZeeuwDepartment of Internal Medicine/Infectious Diseases, University Medical Center Groningen, University of Groningen, The Netherlands. j.de.zeeuw@umcg.nl
Sridevi Duggirala
Willemien A Nienhuis
K Mohammed Abass
Wilson Tuah
Till F Omansen
Tjip S van der Werf
Ymkje Stienstra
Presbyterian University, Ghana · GHUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neopterin is closely associated with activation of the cellular immune system. Neopterin levels differed between controls and patients with Buruli ulcer disease. No differences between patients with or without paradoxical responses were observed. Therefore, neopterin has no value in detecting paradoxical responses among patients with limited Buruli ulcer disease. Neopterin levels were lower in patients receiving clarithromycin. This finding might indicate a slower cellular immune recovery, with possible consequences in future therapy with clarithromycin.

Indexed as

Anti-Bacterial AgentsBuruli UlcerCase-Control StudiesClarithromycinFemaleHumansMaleMycobacterium ulceransNeopterinRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeAnti-Bacterial AgentsClarithromycinNeopterin

Identifiers

PMID23836576
PMCPMC3771288
OpenAlexW2145372534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.