ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2013
Ancestry runs deeper than blood: the evolutionary history of ABO points to cryptic variation of functional importance.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats.Nature communications · 2025Article
- Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats.bioRxiv : the preprint server for biology · 2025Article
- Trans-Specific Polymorphisms Between Cryptic Daphnia Species Affect Fitness and Behavior.Molecular ecology · 2025Article
- Rapid change in red cell blood group systems after the main Out of Africa of Homo sapiens.Scientific reports · 2025Article
- Balancing selection and the functional effects of shared polymorphism in crypticbioRxiv : the preprint server for biology · 2024Article
- Genomic and geographical structure of human cytomegalovirus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- When it doesn't run in the blood(vessels) - events involved in vascular disorders.Biomedical journal · 2023Article
- Haplotype sequence collection of ABO blood group alleles by long-read sequencing reveals putative A1-diagnostic variants.Blood advances · 2023Article
- Burden of malaria infection among individuals of varied blood groups in Kenya.Malaria journal · 2022Article
- ABO blood group and link to COVID-19: A comprehensive review of the reported associations and their possible underlying mechanisms.Microbial pathogenesis · 2022Review
- Three Signatures of Adaptive Polymorphism Exemplified by Malaria-Associated Genes.Molecular biology and evolution · 2021Article
- ABO Blood Types and COVID-19: Spurious, Anecdotal, or Truly Important Relationships? A Reasoned Review of Available Data.Viruses · 2021Review
- Blood groups of Neandertals and Denisova decrypted.PloS one · 2021Article
- Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors.eLife · 2020Article
- Blood type and the microbiome- untangling a complex relationship with lessons from pathogens.Current opinion in microbiology · 2020Review
- Fondness for sugars of enteric viruses confronts them with human glycans genetic diversity.Human genetics · 2020Review
- CharacterisingGut · 2018Article
- Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice.BMC evolutionary biology · 2017Article
- The role of the histoblood ABO group in cancer.Future science OA · 2016Review
- Trans-species polymorphism in humans and the great apes is generally maintained by balancing selection that modulates the host immune response.Human genomics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The ABO histo-blood group, first discovered over a century ago, is found not only in humans but also in many other primate species, with the same genetic variants maintained for at least 20 million years. Polymorphisms in ABO have been associated with susceptibility to a large number of human diseases, from gastric cancers to immune or artery diseases, but the adaptive phenotypes to which the polymorphism contributes remain unclear. We suggest that variation in ABO has been maintained by frequency-dependent or fluctuating selection pressures, potentially arising from co-evolution with gut pathogens. We further hypothesize that the histo-blood group labels A, B, AB, and O do not offer a full description of variants maintained by natural selection, implying that there are unrecognized, functionally important, antigens beyond the ABO group in humans and other primates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.