ArticleEuropean journal of epidemiology2013
Clinical depression, antidepressant use and risk of future cardiovascular disease.
Article in European journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Trajectory of depression occurrence before, during, and after dementia diagnosis: A population-based study.Translational psychiatry · 2026Article
- Depression and incidence of inflammation-related physical health conditions: a cohort study in UK Biobank.BMC psychiatry · 2025Article
- Novel biomarkers of the Framingham risk score in patients with depression: A cross-sectional study.World journal of psychiatry · 2025Article
- Comparison of Risk of Stroke in Patients With and Without Depression: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Association of life-course traumatic brain injury with dementia risk: A nationwide twin study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Injurious falls before, during and after dementia diagnosis: a population-based study.Age and ageing · 2022Article
- Depression increased risk of coronary heart disease: A meta-analysis of prospective cohort studies.Frontiers in cardiovascular medicine · 2022Article
- Article
- Sick leave due to mental disorders, morbidity and mortality: a prospective study of discordant twin pairs.Social psychiatry and psychiatric epidemiology · 2020Article
- Mental Health and Stress Among South Asians.Journal of immigrant and minority health · 2019Review
- Maternal separation diminishes α-adrenergic receptor density and function in renal vasculature from male Wistar-Kyoto rats.American journal of physiology. Renal physiology · 2017Article
- Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2017Article
- Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents.Neuroscience and biobehavioral reviews · 2017Review
- Association between major depression and cardiovascular risk: the role of antidepressant medication.Psychopharmacology · 2016Article
- Article
- Associations between DSM-IV mental disorders and subsequent non-fatal, self-reported stroke.Journal of psychosomatic research · 2015Article
- The Rotterdam Study: 2016 objectives and design update.European journal of epidemiology · 2015Article
- Severity of Depression, Anxious Distress and the Risk of Cardiovascular Disease in a Swedish Population-Based Cohort.PloS one · 2015Article
- Exploring the risk-factor association between depression and incident stroke: a systematic review and meta-analysis.Neuropsychiatric disease and treatment · 2015Article
- Depression and the risk of coronary heart disease: a meta-analysis of prospective cohort studies.BMC psychiatry · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies have shown that depression contributes to a higher risk of developing cardiovascular disease (CVD). Use of antidepressants and its association with CVD development has also been investigated previously but the results have been conflicting. Further, depression and use of antidepressants have been more widely studied in relation to coronary heart disease rather than stroke. A population-based cohort study consisting of 36,654 Swedish elderly twins was conducted with a follow-up of maximum 4 years. Information on exposures, outcomes and covariates were collected from the Swedish national patient registers, the Swedish prescribed drug registry and the Swedish twin registry. Depression and antidepressant use were both associated with CVD development. The risk was most pronounced among depressed patients who did not use antidepressants (HR 1. 48, CI 1.10-2.00). When assessing the two main CVD outcomes coronary heart disease and ischemic stroke separately, the predominant association was found for ischemic stroke while it was absent for coronary heart disease. The association between depression and stroke also remained significant when restricting to depression diagnoses occurring at least 10 years before baseline. The study supports that depression is a possible risk factor for development of CVD. Moreover, the hazard rate for CVD outcomes was highest among depressed patients who had not used antidepressants. The association with clinical depression is more marked in relation to stroke and disappears in relation to development of coronary heart disease.
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Registered trials
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