Evidence map›Paper›PMID 23836309›Full record

ArticleJAMA pediatrics2013

Infant exposures and development of type 1 diabetes mellitus: The Diabetes Autoimmunity Study in the Young (DAISY).

Brittni Frederiksen, Miranda Kroehl, Molly M Lamb, Jennifer Seifert, Katherine Barriga, George S Eisenbarth, Marian Rewers, Jill M Norris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 6 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 6 syntheses or guidelines pooled it, 137 citations in OpenAlex.

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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Brittni FrederiksenColorado School of Public Health, University of Colorado, Aurora.
Miranda Kroehl
Molly M Lamb
Jennifer Seifert
Katherine Barriga
George S Eisenbarth
Marian Rewers
Jill M Norris
Colorado School of Public Health · USUniversity of Colorado Anschutz Medical Campus · US

Funding

UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HUTTON, JOHN C · 2000 to 2010
$14.0M
Natural History of Pre-Diabetic Autoimmunity (DAISY)R01DK032493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 1986 to 2024
$9.3M
NUTRITIONAL ETIOLOGY OF PREDIABETIC AUTOIMMUNITYR01DK049654 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI NORRIS, JILL M · 1997 to 2011
$5.8M
NIDDK NIH HHS P30 DK057516NIDDK NIH HHS P30 DK 57516NIDDK NIH HHS R01 DK032493NIDDK NIH HHS R01 DK049654NIDDK NIH HHS R01-DK32493NIDDK NIH HHS R01-DK49654
6 · The paper itself

Abstract

importanceThe incidence of type 1 diabetes mellitus (T1DM) is increasing worldwide, with the most rapid increase among children younger than 5 years of age.

objectiveTo examine the associations between perinatal and infant exposures, especially early infant diet, and the development of T1DM.

designThe Diabetes Autoimmunity Study in the Young (DAISY) is a longitudinal, observational study.

settingNewborn screening for human leukocyte antigen (HLA) was done at St. Joseph's Hospital in Denver, Colorado. First-degree relatives of individuals with T1DM were recruited from the Denver metropolitan area.

participantsA total of 1835 children at increased genetic risk for T1DM followed up from birth with complete prospective assessment of infant diet. Fifty-three children developed T1DM. EXPOSURES: Early (<4 months of age) and late (≥6 months of age) first exposure to solid foods compared with first exposures at 4 to 5 months of age (referent). MAIN OUTCOME AND MEASURE: Risk for T1DM diagnosed by a physician.

resultsBoth early and late first exposure to any solid food predicted development of T1DM (hazard ratio [HR], 1.91; 95% CI, 1.04-3.51, and HR, 3.02; 95% CI, 1.26-7.24, respectively), adjusting for the HLA-DR genotype, first-degree relative with T1DM, maternal education, and delivery type. Specifically, early exposure to fruit and late exposure to rice/oat predicted T1DM (HR, 2.23; 95% CI, 1.14-4.39, and HR, 2.88; 95% CI, 1.36-6.11, respectively), while breastfeeding at the time of introduction to wheat/barley conferred protection (HR, 0.47; 95% CI, 0.26-0.86). Complicated vaginal delivery was also a predictor of T1DM (HR, 1.93; 95% CI, 1.03-3.61). CONCLUSIONS AND RELEVANCE: These results suggest the safest age to introduce solid foods in children at increased genetic risk for T1DM is between 4 and 5 months of age. Breastfeeding while introducing new foods may reduce T1DM risk.

Indexed as

DietFeeding BehaviorBreast FeedingChildChild, PreschoolDiabetes Mellitus, Type 1Diet SurveysFemaleGenetic MarkersHLA-DQ beta-ChainsHLA-DR3 AntigenHLA-DR4 AntigenHumansInfantInfant, NewbornLongitudinal StudiesGenetic MarkersHLA-DQB1 antigenHLA-DQ beta-ChainsHLA-DR3 AntigenHLA-DR4 Antigen

Identifiers

PMID23836309
PMCPMC4038357
OpenAlexW2060361010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.