Evidence map›Paper›PMID 23835814›Full record

ReviewLab on a chip2014

Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells.

Cesar M Castro, Arezou A Ghazani, Jaehoon Chung, Huilin Shao, David Issadore, Tae-Jong Yoon, Ralph Weissleder, Hakho Lee

Abstract readReview
In one paragraph

Review in Lab on a chip, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Magnetic nanoparticles for cancer theranostics.Biomedical physics & engineering express · 2026
    Review
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  16. Molecular profiling of single circulating tumor cells from lung cancer patients.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cesar M CastroCenter for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Castro.Cesar@mgh.harvard.edu hlee@mgh.harvard.edu.
Arezou A Ghazani
Jaehoon Chung
Huilin Shao
David Issadore
Tae-Jong Yoon
Ralph Weissleder
Hakho Lee

Funding

TREATMENT OF CANCER WITH siRNA DELVIERED BY NANOPARTICLESU54CA119349 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELCHER, ANGELA M. · 2005 to 2009
$20.5M
Dana Farber/Harvard Cancer Consortium Career Development Program in Clinical OncologyK12CA087723 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Tsai Ting · 2002 to 2026
$17.9M
Training Grant in Molecular Imaging Research (MGH/HMS)T32CA079443 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2025
$10.1M
Magnetic nanoswitches for sensing biomoleculesR01EB004626 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2004 to 2012
$3.2M
Novel Clickdyes for Biomedical SensingR01EB010011 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2010 to 2017
$3.1M
MAGNETIC NANOSENSORS FOR BIOMEDICAL ANALYSES OF MICROVESICLESR01HL113156 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO · 2012 to 2016
$2.1M
NCI NIH HHS K12 CA087723NCI NIH HHS K12CA087723-10NCI NIH HHS T32 CA079443NCI NIH HHS T32-CA79443NCI NIH HHS U54 CA119349NCI NIH HHS U54-CA119349NHLBI NIH HHS HHSN268201000044CNHLBI NIH HHS R01 HL113156NHLBI NIH HHS R01HL113156NIBIB NIH HHS R01 EB004626NIBIB NIH HHS R01EB004626NIBIB NIH HHS R01 EB010011NIBIB NIH HHS R01EB010011
6 · The paper itself

Abstract

Accurate detection and profiling of circulating tumor cells (CTCs) is a highly sought after technology to improve cancer management. Such "liquid biopsies" could offer a non-invasive, repeatable window into each patient's tumor, facilitating early cancer diagnosis and treatment monitoring. The rarity of CTCs, approximated at 1 CTC for every billion peripheral blood cells, however, poses significant challenges to sensitive and reliable detection. We have recently developed a new micro-nuclear magnetic resonance (μNMR) platform for biosensing. Through the synergistic integration of microfabrication, nanosensors, and novel chemistries, the μNMR platform offers high detection sensitivity and point-of-care operation, overcoming technical barriers in CTC research. We herein review the μNMR technology with emphasis on its application to CTC detection. Recent advances in the sensing technology will be summarized, followed by the description of the dynamic interplay between our preclinical and clinical CTC studies.

Indexed as

Magnetic Resonance SpectroscopyAntibodiesCyclooctanesHumansMagnetite NanoparticlesMiniaturizationNeoplasm MetastasisNeoplasm ProteinsNeoplasmsNeoplastic Cells, CirculatingAntibodiesCyclooctanesMagnetite NanoparticlesNeoplasm Proteins

Identifiers

PMID23835814
PMCPMC3844052

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.