ArticleJournal of assisted reproduction and genetics2013
Fifteen year follow-up of embryos cryopreserved in cancer patients for fertility preservation.
Article in Journal of assisted reproduction and genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Utilization and Fertility Preservation Outcomes in Women Undergoing Embryo Cryopreservation Before Breast Cancer Treatment: A Meta-Analysis.Clinical breast cancer · 2025Pooled it
- Live birth rate after female fertility preservation for cancer or haematopoietic stem cell transplantation: a systematic review and meta-analysis of the three main techniques; embryo, oocyte and ovarian tissue cryopreservation.Human reproduction (Oxford, England) · 2023Pooled it
- The Oncology Association of Bosnia and Herzegovina's recommendations for fertility preservation in oncologic patients.Bosnian journal of basic medical sciences · 2022Guideline
- Efficacy and Safety of Controlled Ovarian Stimulation With or Without Letrozole Co-administration for Fertility Preservation: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2020Pooled it
- Breast cancer Treatment and Fertility Preservation: A Narrative Review of Impacts, Strategies and Ethical Considerations.Current oncology reports · 2024Review
- Fertility-sparing options for cancer patients.Abdominal radiology (New York) · 2023Review
- Fertility preservation in patients of childbearing age treated for breast cancer: A nationwide cohort study.Breast (Edinburgh, Scotland) · 2022Article
- Hot Topics on Fertility Preservation for Women and Girls-Current Research, Knowledge Gaps, and Future Possibilities.Journal of clinical medicine · 2021Review
- "Will It Affect Our Chances of Having Children?" and Feeling "Like a Ticking Bomb" -The Fertility Concerns and Fears of Cancer Progression and Recurrence in Cancer Treatment Decision-Making Among Young Women Diagnosed With Gynaecological or Breast Cancer.Frontiers in psychology · 2021Article
- The effect of fresh IVF cycle characteristics on frozen embryo transfer (FET) outcomes.JBRA assisted reproduction · 2020Article
- Article
- ESHRE guideline: female fertility preservation.Human reproduction open · 2020Article
- Counseling young women with early breast cancer on fertility preservation.Journal of assisted reproduction and genetics · 2019Article
- Fertility preservation before neoadjuvant chemotherapy in a premenopausal breast cancer patient: a case report.Oxford medical case reports · 2019Article
- Thirteen years' experience in fertility preservation for cancer patients after in vitro fertilization and in vitro maturation treatments.Journal of assisted reproduction and genetics · 2018Article
- Fertility preservation healthcare circuit and networks in cancer patients worldwide: what are the issues?BMC cancer · 2018Review
- Responses to fertility treatment among patients with cancer: a retrospective cohort study.Fertility research and practice · 2018Article
- Cryopreservation of reproductive material before cancer treatment: a qualitative study of health care professionals' views about ways to enhance clinical care.BMC health services research · 2017Article
- Embryo banking among women diagnosed with cancer: a pilot population-based study in New York, Texas, and Illinois.Journal of assisted reproduction and genetics · 2016Article
- Ovarian tissue cryopreservation followed by controlled ovarian stimulation and pick-up of mature oocytes does not impair the number or quality of retrieved oocytes.Journal of ovarian research · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDetermine the outcome of embryo cryopreservation in female oncology patients
methodsThe outcomes of IVF/ICSI cycles in oncology patients over 15 years in a University Teaching Hospital.
resultsForty-two oncology patients (mean 31.9 ± 3.9 years) underwent embryo cryopreservation treatment (n = 33 IVF, n = 6 ICSI). Controlled ovarian stimulation with GnRH antagonist protocol (n = 34; 81 %) yielded fewer oocytes than GnRH agonist protocol (n = 8; 19 %) (9.4 ± 6.3 vs. 15.3 ± 8.9; p = 0.04) respectively. There was no significant difference in mean (±SD) duration of ovarian stimulation (11.6 ± 2.6 vs.10.6 ± 2.7), median gonadotrophin dose (1950 vs. 1670 IU), median day 5-6 oestradiol level (1124 vs.1129 pmol/l) or embryo yield (6.2 ± 4.1 vs. 8.8 ± 4.3; p = 0.07) between GnRH antagonist and agonist treatment cycles respectively. Thirty-nine patients cryopreserved embryos and three had their cycle cancelled. During this study period, of those who cryopreserved embryos, 5 patients underwent 9 frozen-thaw cycles (13 %), resulting in 2 live births (1 twin, 1 singleton, live birth rate 22 %). Six patients died (15 %), 3 conceived naturally (8 %) and 2 couples separated (5 %). Fourteen patients discarded their embryos (36 %). Twenty-two patients' (56 %) have embryos remaining in storage.
conclusionsThis study demonstrates that embryo cryopreservation in female oncology patients gives a satisfactory live birth rate. However, there are concerns regarding cost-effectiveness, resulting from high disposal/non-usage of embryos, and further studies are required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.