ArticleEuropean archives of psychiatry and clinical neuroscience2014
Impact of the anesthetic agents ketamine, etomidate, thiopental, and propofol on seizure parameters and seizure quality in electroconvulsive therapy: a retrospective study.
Article in European archives of psychiatry and clinical neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Ictal electroencephalography and heart rate as treatment criteria in electroconvulsive therapy: a systematic review of the literature.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- A Bayesian framework systematic review and meta-analysis of anesthetic agents effectiveness/tolerability profile in electroconvulsive therapy for major depression.Scientific reports · 2016Pooled it
- Ketamine as a potential treatment for suicidal ideation: a systematic review of the literature.Drugs in R&D · 2015Pooled it
- Investigating the effect of ondansetron in reducing myoclonic movements caused by intravenous administration of etomidate.BMC anesthesiology · 2025Trial
- Effect of quantitative consciousness index on seizure parameters during electroconvulsive therapy in patients with major depressive disorder.World journal of psychiatry · 2024Trial
- Impact comparison of ketamine and sodium thiopental on anesthesia during electroconvulsive therapy in major depression patients with drug-resistant; a double-blind randomized clinical trial.Annals of cardiac anaesthesiaTrial
- Impact of different anesthetic agents (propofol, etomidate, ketamine) on seizure duration and cognitive recovery in electroconvulsive therapy.World journal of methodology · 2026Article
- Effect of ECT-anesthetics on reorientation time.European archives of psychiatry and clinical neuroscience · 2026Article
- Microbiome-Informed Precision Electroconvulsive Therapy: Oral-Gut-Immune Signatures and Seizure Biology as Candidate Predictors of Response-A Narrative Review.Biomedicines · 2026Review
- Tau accumulation increases the susceptibility to effective seizures of electroconvulsive therapy.Translational psychiatry · 2026Article
- The postictal systems window hypothesis of electroconvulsive therapy in major depression.Frontiers in psychiatry · 2026Article
- Article
- Comparison of High-Charge Protocol vs. Dose Titration Protocol in Bilateral ECT: Evaluation of Antidepressant Effectiveness and EEG Parameters.Journal of clinical medicine · 2025Article
- Analysis of clinical characteristics and influencing factors of fever after electroconvulsive therapy: a retrospective study from the Chinese population.Frontiers in psychiatry · 2025Article
- Anesthetic Influence on Electroconvulsive Therapy: A Comprehensive Review.Neuropsychiatric disease and treatment · 2024Review
- Etomidate versus Propofol for Electroconvulsive Therapy in Patients with Major Depressive Disorders in Terms of Clinical Responses to Treatment: A Retrospective Analysis.Brain sciences · 2023Article
- Efficacy and Safety of Subcutaneous Esketamine in the Treatment of Suicidality in Major Depressive Disorder and Bipolar Depression.Clinical drug investigation · 2022Article
- Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Factors Predicting Ictal Quality in Bilateral Electroconvulsive Therapy Sessions.Brain sciences · 2021Article
- Methylome-wide change associated with response to electroconvulsive therapy in depressed patients.Translational psychiatry · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In electroconvulsive therapy (ECT), the use of anesthetics without relevant anticonvulsant properties such as ketamine and etomidate may be favorable for seizure quality. Since there is a relative paucity of studies devoted to this issue, our aim was to compare different anesthetics for ECT regarding their impact on seizure quality and different seizure parameters. We retrospectively compared ketamine (n = 912 anesthesias), etomidate (n = 227 anesthesias), thiopental (n = 2,751 anesthesias), and propofol (n = 42 anesthesias) on their influence on general seizure quality and different seizure parameters by multivariate repeated measurement regression analyses. The use of ketamine and etomidate as anesthetics led to seizures that were overall higher in quality and also longer in motor seizure activity when compared to anesthesia with thiopental and propofol. Ketamine was most favorable concerning central inhibitory potential that was indirectly quantified by concordance and postictal suppression. The worst seizure quality was observed with propofol anesthesia; further, this substance had a negative impact on autonomic activation and seizure duration. Based on the data of this retrospective study, the use of ketamine or etomidate as anesthetic in ECT might be advantageous due to the induction of high-quality seizures.
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