ArticleDiabetes2013
Severe hypoglycemia-induced lethal cardiac arrhythmias are mediated by sympathoadrenal activation.
Article in Diabetes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 166 citations in OpenAlex.
- ACTH Infusion Impairs Baroreflex Sensitivity-Implications for Cardiovascular Hypoglycemia-Associated Autonomic Failure.The Journal of clinical endocrinology and metabolism · 2020Trial
- DEVOTE 3: temporal relationships between severe hypoglycaemia, cardiovascular outcomes and mortality.Diabetologia · 2018Trial
- α-Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome: a multicenter randomized controlled (MACS) study.Cardiovascular diabetology · 2017Trial
- Risk of Cardiovascular Events in Patients With Diabetes Mellitus on β-Blockers.Hypertension (Dallas, Tex. : 1979) · 2017Trial
- Association of mean blood glucose, glycemic variability, and their combined effect with 28-day mortality in critically ill ICU patients with acute myocardial infarction: a MIMIC-IV retrospective cohort study.Journal of thoracic disease · 2026Article
- Ventricular fibrillation triggered by recurrent hypoglycemia in a patient with insulinoma associated with MEN1: case report and review of literature.Endocrine journal · 2026Review
- Ripk1-dependent PANoptosis promotes EndMT and aggravates hypoglycemia-related cardiac fibrosis in diabetes.Journal of translational medicine · 2026Article
- Hypoglycaemia and Cardiac Arrhythmias in Type 1 Diabetes Mellitus: A Mechanistic Review.Journal of personalized medicine · 2026Review
- UK Resuscitation Advanced Life Support Guidelines: Should the Paradigm be Extended?Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Article
- Blood glucose upon return of spontaneous circulation and neurological outcomes following out-of-hospital cardiac arrest.Resuscitation plus · 2025Article
- Current status and mechanistic insights into nontarget coronary lesions in patients with diabetes and early abnormal glucose metabolism.World journal of diabetes · 2025Review
- Determination of the Precision of Glucometers Used in Saudi Arabia.Sensors (Basel, Switzerland) · 2025Article
- A review of hypoglycemia and dextrose treatment in patients with cardiac arrest.Clinical and experimental emergency medicine · 2025Article
- Case Report: Exogenous insulin antibody syndrome complicated with chronic renal failure and long-term history of type 2 diabetes: report of two cases.Frontiers in endocrinology · 2025Article
- Any old iron, man.Experimental physiology · 2025Article
- Enhancing severe hypoglycemia prediction in type 2 diabetes mellitus through multi-view co-training machine learning model for imbalanced dataset.Scientific reports · 2024Article
- Seeking a Treatable Cause of Out-of-Hospital Cardiac Arrest during and after Resuscitation.Journal of clinical medicine · 2024Review
- Norepinephrine mediates heart block during severe hypoglycemia in male rats.Physiological reports · 2024Article
- Advanced cardiovascular physiology in an individual with type 1 diabetes after 10-year ketogenic diet.American journal of physiology. Cell physiology · 2024Article
- Effect of recurrent severe insulin-induced hypoglycemia on the cognitive function and brain oxidative status in the rats.Diabetology & metabolic syndrome · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
For people with insulin-treated diabetes, severe hypoglycemia can be lethal, though potential mechanisms involved are poorly understood. To investigate how severe hypoglycemia can be fatal, hyperinsulinemic, severe hypoglycemic (10-15 mg/dL) clamps were performed in Sprague-Dawley rats with simultaneous electrocardiogram monitoring. With goals of reducing hypoglycemia-induced mortality, the hypotheses tested were that: 1) antecedent glycemic control impacts mortality associated with severe hypoglycemia; 2) with limitation of hypokalemia, potassium supplementation could limit hypoglycemia-associated deaths; 3) with prevention of central neuroglycopenia, brain glucose infusion could prevent hypoglycemia-associated arrhythmias and deaths; and 4) with limitation of sympathoadrenal activation, adrenergic blockers could prevent hypoglycemia-induced arrhythmic deaths. Severe hypoglycemia-induced mortality was noted to be worsened by diabetes, but recurrent antecedent hypoglycemia markedly improved the ability to survive an episode of severe hypoglycemia. Potassium supplementation tended to reduce mortality. Severe hypoglycemia caused numerous cardiac arrhythmias including premature ventricular contractions, tachycardia, and high-degree heart block. Intracerebroventricular glucose infusion reduced severe hypoglycemia-induced arrhythmias and overall mortality. β-Adrenergic blockade markedly reduced cardiac arrhythmias and completely abrogated deaths due to severe hypoglycemia. Under conditions studied, sudden deaths caused by insulin-induced severe hypoglycemia were mediated by lethal cardiac arrhythmias triggered by brain neuroglycopenia and the marked sympathoadrenal response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.