ArticleApplied and environmental microbiology2013
T4-like phage Bp7, a potential antimicrobial agent for controlling drug-resistant Escherichia coli in chickens.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Pooled it
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- Isolation of Bacteriophages and Their Lytic Profile From River and Waste Water Samples in South Western Uganda.Cureus · 2026Article
- Does Phage Therapy Need a Pan-Phage?Pathogens (Basel, Switzerland) · 2024Review
- In vitro evaluation of two novel Escherichia bacteriophages against multiple drug resistant avian pathogenic Escherichia coli.BMC infectious diseases · 2024Article
- Engineering strategies and challenges of endolysin as an antibacterial agent against Gram-negative bacteria.Microbial biotechnology · 2024Review
- Development of a Replication-Deficient Bacteriophage Reporter Lacking an Essential Baseplate Wedge Subunit.Viruses · 2023Article
- Design, Screening, and Characterization of Engineered Phage Endolysins with Extracellular Antibacterial Activity against Gram-Negative Bacteria.Applied and environmental microbiology · 2023Article
- Dietary coated essential oil and organic acid mixture supplementation improves health of broilers infected with avian pathogenicAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Characterization of a lyticFrontiers in microbiology · 2023Article
- Characterization of a lyticFrontiers in microbiology · 2023Article
- Endolysins of bacteriophage vB_Sal-S-S10 can naturally lyse Salmonella enteritidis.BMC veterinary research · 2022Article
- Design of a Bacteriophage Cocktail Active againstAntibiotics (Basel, Switzerland) · 2022Article
- The Expansion of a Single Bacteriophage Leads to Bacterial Disturbance in Gut and Reduction of Larval Growth inFrontiers in immunology · 2022Article
- Isolation, characterization, and genomic analysis of the novel T4-like bacteriophage ΦCJ20.Food science and biotechnology · 2021Article
- A Novel Polyvalent Bacteriophage vB_EcoM_swi3 Infects PathogenicFrontiers in microbiology · 2021Article
- Characterization of a Novel Bacteriophage swi2 Harboring Two Lysins Can Naturally LyseFrontiers in microbiology · 2021Article
- LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.Journal of virology · 2020Article
- Impact of Bacteriophage-Supplemented Drinking Water on thePathogens (Basel, Switzerland) · 2020Article
- The Yersinia Phage X1 Administered Orally Efficiently Protects a Murine Chronic Enteritis Model AgainstFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chicken-pathogenic Escherichia coli is severely endangering the poultry industry in China and worldwide, and antibiotic therapy is facing an increasing problem of antibiotic resistance. Bacteriophages can kill bacteria with no known activity in human or animal cells, making them an attractive alternative to antibiotics. In this study, we present the characteristics of a novel virulent bacteriophage, Bp7, specifically infecting pathogenic multidrug-resistant E. coli. Phage Bp7 was isolated from chicken feces. Bp7 belongs to the family Myoviridae, possessing an elongated icosahedral head and contractile sheathed tail. It has a 168-kb double-stranded DNA genome. For larger yields, its optimal multiplicity of infection (MOI) to infect E. coli was about 0.001. The latent period was 10 to 15 min, and the burst size was 90 PFU/infected cell. It was stable both at pH 5.0 to 10.0 and at 40°C or 50°C for at least 1 h. Bp7 could infect 46% of pathogenic clinical E. coli strains. Bp7 harbored 791 open reading frames (ORFs) and 263 possible genes. Among the 263 genes, 199 possessed amino acid sequence identities with ORFs of phage T4, 62 had identities with other T4-like phages, and only one lacked any database match. The genome of Bp7 manifested obvious division and rearrangement compared to phages T4, JS98, and IME08. Bp7 is a new member of the "T4-like" genus, family Myoviridae. Its wide host range, strong cell-killing activity, and high stability to pH make it an alternative to antimicrobials for controlling drug-resistant E. coli in chickens.
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