ArticleBMC cancer2013
Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk: a case-control study in Japan.
Article in BMC cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Polymorphisms in the FTO Gene and Their Association With Cancer Risk: A Comprehensive Review and Meta-Analysis.Cancer reports (Hoboken, N.J.) · 2025Pooled it
- Are the FTO Gene Polymorphisms Associated with Colorectal Cancer? A Meta-analysis.Journal of gastrointestinal cancer · 2021Pooled it
- Pooled it
- A novel biclustering algorithm for mining m6A co-methylation patterns based on beta-binomial distribution and data screening strategy.PLoS computational biology · 2026Article
- Article
- Screening of Exons 4-9 Polymorphisms ofArchives of Razi Institute · 2023Article
- FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review.Frontiers in oncology · 2023Review
- The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake.Journal of cellular and molecular medicine · 2022Article
- Targeting FTO Suppresses Pancreatic Carcinogenesis via Regulating Stem Cell Maintenance and EMT Pathway.Cancers · 2022Article
- Research advances of N6-methyladenosine in diagnosis and therapy of pancreatic cancer.Journal of clinical laboratory analysis · 2022Review
- Review
- FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms.International journal of molecular sciences · 2022Review
- Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers.Helicobacter · 2022Article
- Comprehensive mutations analyses ofFrontiers in nutrition · 2022Article
- FTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma.Pharmacogenomics and personalized medicine · 2021Article
- The Association of Fat-Mass-and Obesity-Associated Gene Polymorphism (rs9939609) With Colorectal Cancer: A Case-Control Study.Frontiers in oncology · 2021Article
- N6-Methyladenosine Modification of PTTG3P Contributes to Colorectal Cancer ProliferationFrontiers in oncology · 2021Article
- mFrontiers in oncology · 2021Article
- NInternational journal of biological sciences · 2021Review
- RNA mInnovation (Cambridge (Mass.)) · 2020Review
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is clear that genetic variations in the fat mass and obesity-associated (FTO) gene affect body mass index and the risk of obesity. Given the mounting evidence showing a positive association between obesity and pancreatic cancer, this study aimed to investigate the relation between variants in the FTO gene, obesity and pancreatic cancer risk.
methodsWe conducted a hospital-based case-control study in Japan to investigate whether genetic variations in the FTO gene were associated with pancreatic cancer risk. We genotyped rs9939609 in the FTO gene of 360 cases and 400 control subjects. An unconditional logistic model was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for the association between rs9939609 and pancreatic cancer risk.
resultsThe minor allele frequency of rs9939609 was 0.18 among control subjects. BMI was not associated with pancreatic cancer risk. Compared with individuals with the common homozygous TT genotype, those with the heterozygous TA genotype and the minor homozygous AA genotype had a 48% (OR=1.48; 95%CI: 1.07-2.04), and 66% increased risk (OR=1.66; 95%CI: 0.70-3.90), respectively, of pancreatic cancer after adjustment for sex, age, body mass index, cigarette smoking and history of diabetes. The per-allele OR was 1.41 (95%CI: 1.07-1.85). There were no significant interactions between TA/AA genotypes and body mass index.
conclusionsOur findings indicate that rs9939609 in the FTO gene is associated with pancreatic cancer risk in Japanese subjects, possibly through a mechanism that is independent of obesity. Further investigation and replication of our results is required in other independent samples.
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