ArticleVisual neuroscience2013
Recurrent axon collaterals of intrinsically photosensitive retinal ganglion cells.
Article in Visual neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 78 citations in OpenAlex.
- Diversity and Feature Selectivity of Primate Retinal Ganglion Cells.Annual review of vision science · 2026Review
- The Effect of Optic Nerve Crush on Lens-Induced Myopia in Mice.Ophthalmology science · 2026Article
- Blue-Light Stimulation for Myopia Prevention: Only Retinal but Not Optic Disc Stimulation Modulates the Pattern ERG.Life (Basel, Switzerland) · 2025Article
- Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension.Antioxidants (Basel, Switzerland) · 2024Article
- Increase in choroidal thickness after blue light stimulation of the blind spot in young adults.Bioelectronic medicine · 2024Article
- Melanopsin-mediated amplification of cone signals in the human visual cortex.Proceedings. Biological sciences · 2024Article
- Blue-light stimulation of the blind-spot constricts the pupil and enhances contrast sensitivity.PloS one · 2023Article
- Characterization of non-alpha retinal ganglion cell injury responses reveals a possible block to restoring ipRGC function.Experimental neurology · 2022Article
- Synaptic inputs to displaced intrinsically-photosensitive ganglion cells in macaque retina.Scientific reports · 2022Article
- Tools and Biomarkers for the Study of Retinal Ganglion Cell Degeneration.International journal of molecular sciences · 2022Review
- Intrinsically photosensitive retinal ganglion cells in glaucoma.Frontiers in cellular neuroscience · 2022Review
- Burning the candle at both ends: Intraretinal signaling of intrinsically photosensitive retinal ganglion cells.Frontiers in cellular neuroscience · 2022Review
- Melanopic stimulation does not alter psychophysical threshold sensitivity for luminance flicker.Scientific reports · 2021Article
- Photoreceptive Ganglion Cells Drive Circuits for Local Inhibition in the Mouse Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Retinal ganglion cell interactions shape the developing mammalian visual system.Development (Cambridge, England) · 2020Review
- Crosstalk: The diversity of melanopsin ganglion cell types has begun to challenge the canonical divide between image-forming and non-image-forming vision.The Journal of comparative neurology · 2020Review
- Effects of Mydriatics on Rod/Cone- and Melanopsin-driven Pupil Responses.Optometry and vision science : official publication of the American Academy of Optometry · 2020Article
- Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior.Neuron · 2019Review
- Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina.Physiological reviews · 2019Review
- Rods contribute to the light-induced phase shift of the retinal clock in mammals.PLoS biology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Retinal ganglion cells (RGCs), the output neurons of the retina, have axons that project via the optic nerve to diverse targets in the brain. Typically, RGC axons do not branch before exiting the retina and thus do not provide it with synaptic feedback. Although a small subset of RGCs with intraretinal axon collaterals has been previously observed in human, monkey, cat, and turtle, their function remains unknown. A small, more recently identified population of RGCs expresses the photopigment melanopsin. These intrinsically photosensitive retinal ganglion cells (ipRGCs) transmit an irradiance-coding signal to visual nuclei in the brain, contributing both to image-forming vision and to several nonimage-forming functions, including circadian photoentrainment and the pupillary light reflex. In this study, using melanopsin immunolabeling in monkey and a genetic method to sparsely label the melanopsin cells in mouse, we show that a subgroup of ipRGCs have axons that branch en route to the optic disc, forming intraretinal axon collaterals that terminate in the inner plexiform layer of the retina. The previously described collateral-bearing population identified by intracellular dye injection is anatomically indistinguishable from the collateral-bearing melanopsin cells identified here, suggesting they are a subset of the melanopsin-expressing RGC type and may therefore share its functional properties. Identification of an anatomically distinct subpopulation in mouse, monkey, and human suggests this pathway may be conserved in these and other species (turtle and cat) with intraretinal axon collaterals. We speculate that ipRGC axon collaterals constitute a likely synaptic pathway for feedback of an irradiance signal to modulate retinal light responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.