ArticleThe British journal of cancer. Supplement1990
Quantitation of antibody uptake in spontaneous metastases.
Article in The British journal of cancer. Supplement, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Monoclonal antibody uptake in B-cell lymphomas: experimental studies in nude mouse xenografts.Cancer immunology, immunotherapy : CII · 1993Article
- Monoclonal antibody accumulation in experimental and spontaneous lung metastases of human malignant melanoma in rodents.Journal of cancer research and clinical oncology · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A procedure of high resolution quantitative autoradiography was established and tested in the murine ESb-Mp lymphoma system. Using 125I-labelled antibody 12-15A, liver metastases with diameters down to 100 microns were identified and intralesional radioiodine accumulation was assessed as % injected dose (iD) g-1. Uptake was found to be highest in intermediate size metastases, i.e., up to 100% iD g-1 in 1 mm lesions, while it gradually declined with both increasing and decreasing diameters of metastases. Lower uptake in large size metastases was due to a marked non-uniformity in radioactivity retention, while lower uptake in small metastases was possibly due to insufficient access of the antibody to intrahepatic processes which have not yet established an autonomous blood supply.
Indexed as
Identifiers
2383482PMC2149523W289879470What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.