ArticleBMC microbiology2013
Potential of bacteriophage ΦAB2 as an environmental biocontrol agent for the control of multidrug-resistant Acinetobacter baumannii.
Article in BMC microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- A Rapid Screening Strategy for Secondary Bacteriophages to Counter Phage Resistance in Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Characterization and Complete Genomic Analysis of a Novel Bacteriophage BUCT775 forInternational journal of molecular sciences · 2025Article
- The intricacies ofFrontiers in microbiology · 2025Review
- Potential Usefulness of Bacteriophages for the Treatment of Multidrug-ResistantThe Malaysian journal of medical sciences : MJMS · 2023Review
- A Bacteriophage Microgel Effectively Treats the Multidrug-ResistantPharmaceuticals (Basel, Switzerland) · 2023Article
- Bacteriophages in Infectious Diseases and Beyond-A Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
- Bacteriophages as therapeutic & disinfectant agents to tackle multidrug-resistantThe Indian journal of medical research · 2023Article
- Potential Use of a Combined Bacteriophage-Probiotic Sanitation System to Control Microbial Contamination and AMR in Healthcare Settings: A Pre-Post Intervention Study.International journal of molecular sciences · 2023Article
- In Vitro Techniques and Measurements of Phage Characteristics That Are Important for Phage Therapy Success.Viruses · 2022Review
- Detection of theArchives of Razi Institute · 2022Article
- Bacteriophages as a Potential 360-Degree Pathogen Control Strategy.Microorganisms · 2021Review
- Characterization of a Novel Bacteriophage swi2 Harboring Two Lysins Can Naturally LyseFrontiers in microbiology · 2021Article
- Topical application of bacteriophages for treatment of wound infections.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Development of a Biocontrol Method Applying Bacteriophage-Containing Aerosol againstMicroorganisms · 2019Article
- Efficacy of Bacteriophages inAnnals of dermatology · 2019Article
- Semi-Solid and Solid Dosage Forms for the Delivery of Phage Therapy to Epithelia.Pharmaceuticals (Basel, Switzerland) · 2018Review
- High-touch surfaces: microbial neighbours at hand.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Review
- Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains.Scientific reports · 2017Article
- Prospects of Phage Application in the Treatment of Acne Caused byFrontiers in microbiology · 2017Review
- Characterization and formulation into solid dosage forms of a novel bacteriophage lytic against Klebsiella oxytoca.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultidrug-resistant Acinetobacter baumannii (MDRAB) is associated with nosocomial infections worldwide. To date, the use of a phage to prevent infections caused by MDRAB has not been demonstrated.
resultsThe MDRAB-specific phage ϕAB2 was stable at 4°C and pH 7 in 0.5% chloroform solution, and showed a slight decrease in plaque-forming units (PFU)/ml of 0.3-0.9 log after 330 days of storage. The addition of ϕAB2 at a concentration of at least 10⁵ PFU/ml to an A. baumannii M3237 suspension killed >99.9% of A. baumannii M3237 after 5 min, regardless of A. baumannii M3237 concentration (10⁴, 10⁵, or 10⁶ colony-forming units (CFU)/ml). The addition of ϕAB2 at a concentration of 10⁸ PFU/slide (>10⁷ PFU/cm²) to glass slides containing A. baumannii M3237 at 10⁴, 10⁵, or 10⁶ CFU/slide, significantly reduced bacterial numbers by 93%, 97%, and 99%, respectively. Thus, this concentration is recommended for decontamination of glass surfaces. Moreover, infusion of ϕAB2 into 10% glycerol exhibited strong anti-MDRAB activity (99.9% reduction), even after 90 days of storage. Treatment of a 10% paraffin oil-based lotion with ϕAB2 significantly reduced (99%) A. baumannii M3237 after 1 day of storage. However, ϕAB2 had no activity in the lotion after 1 month of storage.
conclusionsPhages may be useful for reducing MDRAB contamination in liquid suspensions or on hard surfaces. Phages may also be inoculated into a solution to produce an antiseptic hand wash. However, the phage concentration and incubation time (the duration of phage contact with bacteria) should be carefully considered to reduce the risk of MDRAB contamination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.