ArticleRespiratory research2013
Neutrophil adhesion molecules in experimental rhinovirus infection in COPD.
Article in Respiratory research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Trial
- COPD: the role of neutrophils in inflammation, pathophysiology, and as drug targets.Clinical science (London, England : 1979) · 2025Review
- Neutrophil extracellular traps promote immunopathogenesis of virus-induced COPD exacerbations.Nature communications · 2024Article
- Inhibition of Recruitment and Activation of Neutrophils by Pyridazinone-Scaffold-Based Compounds.International journal of molecular sciences · 2022Article
- Our evolving view of neutrophils in defining the pathology of chronic lung disease.Immunology · 2021Review
- Bacterial and viral infections and related inflammatory responses in chronic obstructive pulmonary disease.Annals of medicine · 2021Review
- Neutrophils in respiratory viral infections.Mucosal immunology · 2021Review
- Definition, Causes, Pathogenesis, and Consequences of Chronic Obstructive Pulmonary Disease Exacerbations.Clinics in chest medicine · 2020Review
- The Implication of Oxidative Stress and AMPK-Nrf2 Antioxidative Signaling in Pneumonia Pathogenesis.Frontiers in endocrinology · 2020Review
- Endotracheal intubation results in acute tracheal damage induced by mtDNA/TLR9/NF-κB activity.Journal of leukocyte biology · 2019Article
- Blood Neutrophils In COPD But Not Asthma Exhibit A Primed Phenotype With Downregulated CD62L Expression.International journal of chronic obstructive pulmonary disease · 2019Article
- Recombinant Poliovirus for Cancer Immunotherapy.Annual review of medicine · 2018Review
- Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD.Chest · 2016Article
- Similar activation state of neutrophils in sputum of asthma patients irrespective of sputum eosinophilia.Clinical and experimental immunology · 2015Article
- A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD.Clinical science (London, England : 1979) · 2015Article
- Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.Pulmonary pharmacology & therapeutics · 2015Review
- Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD.BMC pulmonary medicine · 2014Article
- Experimental rhinovirus infection in COPD: implications for antiviral therapies.Antiviral research · 2014Review
- Immunotherapy reduces allergen-mediated CD66b expression and myeloperoxidase levels on human neutrophils from allergic patients.PloS one · 2014Article
- High expression of neutrophil and monocyte CD64 with simultaneous lack of upregulation of adhesion receptors CD11b, CD162, CD15, CD65 on neutrophils in severe COVID-19.Therapeutic advances in infectious diseaseArticle
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundCOPD exacerbations are associated with neutrophilic airway inflammation. Adhesion molecules on the surface of neutrophils may play a key role in their movement from blood to the airways. We analysed adhesion molecule expression on blood and sputum neutrophils from COPD subjects and non-obstructed smokers during experimental rhinovirus infections.
methodsBlood and sputum were collected from 9 COPD subjects and 10 smoking and age-matched control subjects at baseline, and neutrophil expression of the adhesion molecules and activation markers measured using flow cytometry. The markers examined were CD62L and CD162 (mediating initial steps of neutrophil rolling and capture), CD11a and CD11b (required for firm neutrophil adhesion), CD31 and CD54 (involved in neutrophil transmigration through the endothelial monolayer) and CD63 and CD66b (neutrophil activation markers). Subjects were then experimentally infected with rhinovirus-16 and repeat samples collected for neutrophil analysis at post-infection time points.
resultsAt baseline there were no differences in adhesion molecule expression between the COPD and non-COPD subjects. Expression of CD11a, CD31, CD62L and CD162 was reduced on sputum neutrophils compared to blood neutrophils. Following rhinovirus infection expression of CD11a expression on blood neutrophils was significantly reduced in both subject groups. CD11b, CD62L and CD162 expression was significantly reduced only in the COPD subjects. Blood neutrophil CD11b expression correlated inversely with inflammatory markers and symptom scores in COPD subjects.
conclusionFollowing rhinovirus infection neutrophils with higher surface expression of adhesion molecules are likely preferentially recruited to the lungs. CD11b may be a key molecule involved in neutrophil trafficking in COPD exacerbations.
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