ArticleEnvironmental science & technology2013
Global transcriptome profiling reveals molecular mechanisms of metal tolerance in a chronically exposed wild population of brown trout.
Article in Environmental science & technology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 90 citations in OpenAlex.
- Osmoregulatory disruption and metal bioaccumulation in the estuarine fish Centropomus parallelus exposed to settleable atmospheric particulate matter.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- The Genomic Signature and Transcriptional Response of Metal Tolerance in Brown Trout Inhabiting Metal-Polluted Rivers.Molecular ecology · 2025Article
- Multi-metal-resistant Staphylococcus warneri strain TWSL_1: revealing heavy metal-resistant genomic features by whole-genome sequencing and analysis.Access microbiology · 2025Article
- Metal Toxicity: Effects on Energy Metabolism in Fish.International journal of molecular sciences · 2024Review
- Amphibian tolerance to arsenic: microbiome-mediated insights.Scientific reports · 2024Article
- Article
- Laboratory versus wild populations: the importance of population origin in aquatic ecotoxicology.Environmental science and pollution research international · 2022Review
- Divergence in heritable life history traits suggests potential for local adaptation and trade-offs associated with a coal ash disposal site.Evolutionary applications · 2021Article
- De novo assembly and characterization of the liver transcriptome of Mugil incilis (lisa) using next generation sequencing.Scientific reports · 2020Article
- Sublethal exposure to copper supresses the ability to acclimate to hypoxia in a model fish species.Aquatic toxicology (Amsterdam, Netherlands) · 2019Article
- Functional genomic characterization of metallothioneins in brown trout (Salmo trutta L.). using synthetic genetic analysis.Scientific reports · 2019Article
- Defence mechanisms: the role of physiology in current and future environmental protection paradigms.Conservation physiology · 2018Article
- Transcriptomic responses of the endangered freshwater mussel Margaritifera margaritifera to trace metal contamination in the Dronne River, France.Environmental science and pollution research international · 2017Article
- Adaptive capabilities and fitness consequences associated with pollution exposure in fish.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Article
- Human mining activity across the ages determines the genetic structure of modern brown trout (Salmo trutta L.) populations.Evolutionary applications · 2015Article
- De novo assembly of the Carcinus maenas transcriptome and characterization of innate immune system pathways.BMC genomics · 2015Article
- Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels.Ecotoxicology (London, England) · 2015Article
- The role of biomarkers in the assessment of aquatic ecosystem health.Integrated environmental assessment and management · 2014Review
- RNA-Seq technology and its application in fish transcriptomics.Omics : a journal of integrative biology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Worldwide, a number of viable populations of fish are found in environments heavily contaminated with metals, including brown trout (Salmo trutta) inhabiting the River Hayle in South-West of England. This population is chronically exposed to a water-borne mixture of metals, including copper and zinc, at concentrations lethal to naïve fish. We aimed to investigate the molecular mechanisms employed by the River Hayle brown trout to tolerate high metal concentrations. To achieve this, we combined tissue metal analysis with whole-transcriptome profiling using RNA-seq on an Illumina platform. Metal concentrations in the Hayle trout, compared to fish from a relatively unimpacted river, were significantly increased in the gills, liver and kidney (63-, 34- and 19-fold respectively), but not the gut. This confirms that these fish can tolerate considerable metal accumulation, highlighting the importance of these tissues in metal uptake (gill), storage and detoxification (liver, kidney). We sequenced, assembled and annotated the brown trout transcriptome using a de novo approach. Subsequent gene expression analysis identified 998 differentially expressed transcripts and functional analysis revealed that metal- and ion-homeostasis pathways are likely to be the most important mechanisms contributing to the metal tolerance exhibited by this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.