ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2012
Associations between high density lipoprotein mean particle size and serum paraoxonase-1 activity.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- LCAT deficiency: a systematic review with the clinical and genetic description of Mexican kindred.Lipids in health and disease · 2021Pooled it
- A Meta-Analysis of Oxidative Stress Markers in Depression.PloS one · 2015Pooled it
- Prolonged bedrest reduces plasma high-density lipoprotein levels linked to markedly suppressed cholesterol efflux capacity.Scientific reports · 2020Trial
- Effect of yerba mate and green tea on paraoxonase and leptin levels in patients affected by overweight or obesity and dyslipidemia: a randomized clinical trial.Nutrition journal · 2019Trial
- Native High-Density Lipoproteins (HDL) with Higher Paraoxonase Exerts a Potent Antiviral Effect against SARS-CoV-2 (COVID-19), While Glycated HDL Lost the Antiviral Activity.Antioxidants (Basel, Switzerland) · 2021Article
- Ischemia-Modified Albumin, Creatinine, And Paraoxonase-1 Levels in Serum of Patients Undergoing Intravenous Contrast-Enhanced Computed Tomography and Its Association with Contrast-Induced Nephropathy.Reports of biochemistry & molecular biology · 2019Article
- Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals.Scientific reports · 2019Article
- Increased Levels of Acetylcholinesterase, Paraoxonase 1, and Copper in Patients with Moderate Depression- a Preliminary Study.Reports of biochemistry & molecular biology · 2019Article
- Paraoxonase 1 Activity, Lipid Profile, and Atherogenic Indexes Status in Coronary Heart Disease.Reports of biochemistry & molecular biology · 2017Article
- Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution.Lipids in health and disease · 2016Article
- Biochemical effects of oleuropein in gentamicin-induced nephrotoxicity in rats.ARYA atherosclerosis · 2016Article
- Article
- p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample.Arquivos brasileiros de cardiologia · 2015Article
- High density lipoproteins: Measurement techniques and potential biomarkers of cardiovascular risk.BBA clinical · 2015Review
- Antioxidant and lipid-regulating effects of probucol combined with atorvastatin in patients with acute coronary syndrome.Journal of thoracic disease · 2015Article
- Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity.Redox report : communications in free radical research · 2014Article
- Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease.Pharmacogenomics · 2013Review
- Serum paraoxonase 1 activity is associated with fatty acid composition of high density lipoprotein.Disease markers · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh density lipoprotein (HDL) particles are heterogeneous in composition, structure, size, and may differ in conferring protection against cardiovascular disease. HDL associated enzyme, paraoxonase-1 (PON1), has an important role in attenuation of atherogenic low density lipoprotein (LDL) oxidation. The aim of this study was to investigate the associations between HDL particle size and PON1 activity in relation to serum HDL cholesterol (HDL-C) levels. MATERIALS AND
methodsOne hundred and forty healthy subjects contributed to this study. HDL was separated by sequential ultracentrifugation and its size was estimated by dynamic light scattering. Paraoxonase activity was measured spectrophotometrically using paraoxon as substrate.
resultsResults of this study showed that PON1 activity had negative correlations with HDL mean particle size (r = -0.22, P < 01), HDL2/HDL3 ratio, and serum HDL-C levels (r = -0.25, P < 0.01). HDL mean particle size and HDL2/HDL3 ratio had negative correlation with body mass index (BMI), waist hip ratio (WHR), and serum triglyceride (TG) levels, and positive correlation with serum HDL-C levels. Serum HDL-C levels had significant positive correlations with age, total cholesterol (TC), and apolipoprotein A-I (apo A-I) and significant negative correlation with BMI, WHR, and TG.
conclusionBased on the results of this study, determination of HDL mean particle size beside the serum PON1 activity may help to better understand the CAD risks, pathogenesis, and prognosis, and may also help to design therapeutic protocols toward beneficial modifications of HDL characteristics.
Indexed as
Identifiers
23833575PMC3702082W2262750373What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.