ArticleToxicology international2013
Induction of chronic renal failure in goats using Cisplatin: a new animal model.
Article in Toxicology international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Selection of a suitable animal model to evaluate secretion of drugs in the human milk: a systematic approach.Xenobiotica; the fate of foreign compounds in biological systems · 2024Article
- Replacing Concentrate with Yeast- or EM-Fermented Cassava Peel (YFCP or EMFCP): Effects on the Feed Intake, Feed Digestibility, Rumen Fermentation, and Growth Performance of Goats.Animals : an open access journal from MDPI · 2023Article
- Alleviating chronic kidney disease progression through modulating the critical genus of gut microbiota in a cisplatin-induced Lanyu pig model.Journal of food and drug analysis · 2020Article
- Evaluation of wet cupping therapy on the arterial and venous blood parameters in healthy Arabian horses.Veterinary world · 2018Article
- Some hematological and biochemical parameters of different goat breeds in Sultanate of Oman "A preliminary study".Veterinary world · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cisplatin was administered at the dose rate of 30 mg m(-2) daily intravenously consecutive for 7 days in goats. Blood samples (2 ml) were collected from each goat at '0' hr and then at weekly interval and centrifuged immediately at 3000 rpm for 20 min to separate plasma, which were used for estimation of blood urea nitrogen (BUN), plasma creatinine (CRT), gamma glutamyltransferase (γGT), and glomerular filtration rate (GFR). Total volume of urine of each goat was recorded, and 5 ml of urine samples were collected for estimation of GFR. Blood urea nitrogen started to increase significantly from 7 days post-dosing and achieved a peak on day 14. Higher values persisted up to 91 days. Plasma creatinine level was significantly higher in all samples on day 7 onwards, and it was maintained up to day 91 post-dosing compared to control samples ('0' day) whilst GFR declined significantly from day 7 and attained a minimum values on day 70. GFR was almost <60% up to 91 days. The signs like emaciation, loss of body weight, and oliguria were observed. The values of all 4 biomarkers showed a chronic renal failure in goats.
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