ArticleToxicology international2013
Immunotoxic and genotoxic potential of arsenic and its chemical species in goats.
Article in Toxicology international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Goat hair as a bioindicator of environmental contaminants and adrenal activation during vertical transhumance.Frontiers in veterinary science · 2023Article
- Experimental acute arsenic toxicity in Balb/c mice: organic markers and splenic involvementBiomedica : revista del Instituto Nacional de Salud · 2021Article
- Toxicity in Goats Exposed to Arsenic in the Region Lagunera, Northern Mexico.Veterinary sciences · 2020Article
- Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study.Environmental health : a global access science source · 2020Article
- Impact of environmental contaminants on reproductive health of male domestic ruminants: a review.Environmental science and pollution research international · 2020Review
- Arsenic and Immune Response to Infection During Pregnancy and Early Life.Current environmental health reports · 2017Review
- Ameliorative Effect of Tephrosia Purpurea in Arsenic-induced Nephrotoxicity in Rats.Toxicology international · 2014Article
- Efficacy of crude extract of Emblica officinalis (amla) in arsenic-induced oxidative damage and apoptosis in splenocytes of mice.Toxicology international · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study investigated the immunotoxic and genotoxic effect of arsenic and its different species on goats. It was found that arsenic causes haematological crisis. Histopathological changes in spleen and reduced serum immunoglobulin G level without any changes in formazan production in arsenic-treated animals indicated that arsenic is toxic to the humoral immune system. Increased caspase-3 production and higher number of TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling)-positive bone marrow cells along with oligonucleosomal DNA fragmentation on agarose gel suggested apoptosis induction by arsenic in the bone marrow cells of goat. Total arsenic concentration in the plasma, bone marrow, and spleen of the exposed group was, respectively, 1.22 ± 0.11, 2.20 ± 0.21, and 3.39 ± 0.14 ppm. Speciation study revealed that arsenite and organoarsenic were the major arsenic species in these samples, suggesting their role in immunotoxic and genotoxic potential in goats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.