ArticleIndian journal of pharmacology
Differences in morphine-induced antinociception in male and female offspring born of morphine exposed mothers.
Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Gestational Opioid Exposure: From Morphine to MOUD - How Opioids Impact Offspring Development and Maternal Care.Current topics in behavioral neurosciences · 2025Review
- Morphine Perinatal Exposure Induces Long-Lasting Negative Emotional States in Adult Offspring Rodents.Pharmaceutics · 2021Article
- Consequences of Parental Opioid Exposure on Neurophysiology, Behavior, and Health in the Next Generations.Cold Spring Harbor perspectives in medicine · 2021Review
- Modeling prenatal opioid exposure in animals: Current findings and future directions.Frontiers in neuroendocrinology · 2018Review
- Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure.Neuropharmacology · 2017Article
- An examination of sex differences in the effects of early-life opiate and alcohol exposure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAntinociceptive effect of morphine in offspring born of mothers that received saline or morphine during the gestation period was investigated. MATERIALS AND
methodsWistar rats (200-250 g) received saline, morphine 0.5 mg/kg or 5 mg/kg during gestation days 14-16. All pups after weaning were isolated treatment/sex dependently and were allowed to fully mature. The antinociceptive effect of morphine was assessed in formalin test. Morphine (0.5-7.5 mg/kg) or saline (1 ml/kg) was injected intraperitoneally 10 min before formalin (50 μl of 2.5% solution in right hind-paw).
resultsMale offspring born of saline-treated mothers were less morphine-sensitive than females. On the contrary, male offspring exposed prenatally to morphine (5 mg/kg) were more sensitive to morphine-induced antinociceptive response in formalin test. However, no difference in antinociceptive effect was observed amongst offspring of either sex born of mothers treated with morphine 0.5 mg/kg, identifying a lower dose effect of the opioid.
conclusionThe exposure to morphine during the developmental period may result in altered development of tolerance to morphine and thus involved in drug abuse.
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Registered trials
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