ReviewJournal of the American Society of Nephrology : JASN2013
Estimation of glomerular podocyte number: a selection of valid methods.
Review in Journal of the American Society of Nephrology : JASN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- The Life of a Kidney Podocyte.Acta physiologica (Oxford, England) · 2025Review
- Continuous increase in podocyte numbers in the first 36 months of life-insights from forensic autopsies in Japanese children.Pediatric nephrology (Berlin, Germany) · 2025Article
- Effects of Prothrombin on Podocytopathy and Proteinuria in Glomerular Disease.Journal of the American Society of Nephrology : JASN · 2025Article
- Article
- Artificial intelligence assists identification and pathologic classification of glomerular lesions in patients with diabetic nephropathy.Journal of translational medicine · 2024Article
- Quantifying Podocyte Number in a Small Sample Size of Glomeruli with CUBIC to Evaluate Podocyte Depletion of db/db Mice.Journal of diabetes research · 2023Article
- PodoCount: A Robust, Fully Automated, Whole-Slide Podocyte Quantification Tool.Kidney international reports · 2022Article
- PodoSighter: A Cloud-Based Tool for Label-Free Podocyte Detection in Kidney Whole-Slide Images.Journal of the American Society of Nephrology : JASN · 2021Article
- An Introduction to Stereology with Applications to the Glomerulus.Glomerular diseases · 2021Review
- Deep learning-based molecular morphometrics for kidney biopsies.JCI insight · 2021Article
- MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.International journal of biological sciences · 2021Article
- The Presence and Location of Podocytes in Glomeruli as Affected by Diabetes Mellitus.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.American journal of physiology. Renal physiology · 2017Article
- Can podocytes be regenerated in adults?Current opinion in nephrology and hypertension · 2017Review
- Article
- Krüppel-Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers.Journal of the American Society of Nephrology : JASN · 2017Article
- Validation of a Three-Dimensional Method for Counting and Sizing Podocytes in Whole Glomeruli.Journal of the American Society of Nephrology : JASN · 2016Article
- Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure.Journal of the American Society of Nephrology : JASN · 2016Article
- Observational
- Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria.Kidney international · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The podocyte depletion hypothesis has emerged as an important unifying concept in glomerular pathology. The estimation of podocyte number is therefore often a critical component of studies of progressive renal diseases. Despite this, there is little uniformity in the biomedical literature with regard to the methods used to estimate this important parameter. Here we review a selection of valid methods for estimating podocyte number: exhaustive enumeration method, Weibel and Gomez method, disector/Cavalieri combination, disector/fractionator combination, and thick-and-thin section method. We propose the use of the disector/fractionator method for studies in which controlled sectioning of tissue is feasible, reserving the Weibel and Gomez method for studies based on archival or routine pathology material.
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