Evidence map›Paper›PMID 23832844›Full record

ReviewCurrent urology reports2013

From physiology to pharmacy: developments in the pathogenesis and treatment of recurrent urinary tract infections.

Jennifer A Silverman, Henry L Schreiber, Thomas M Hooton, Scott J Hultgren

Open access · bronzeAbstract readReview
In one paragraph

Review in Current urology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Efficacy ofClinics and practice · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. A cynomolgus monkeyInfection and immunity · 2024
    Article
  12. Article
  13. Article
  14. Urinary Tract Infections Caused by UropathogenicInternational journal of molecular sciences · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jennifer A SilvermanDepartment of Molecular Microbiology and Microbial Pathogenesis; Center for Women's Infectious Disease Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8230, Saint Louis, MO, 63110, USA.
Henry L Schreiber
Thomas M Hooton
Scott J Hultgren
Washington University in St. Louis · USUniversity of Miami · US

Funding

pan-Genome of E.coli in the bladder and gut of women with recurrent UTIP50DK064540 · NIDDK · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2002 to 2017
$17.9M
Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
Human MAIT celis in airway mucosal immune responses to intracellular infectionsU01AI095776 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M. · 2011 to 2015
$8.9M
MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
PATHOGENIC FIBER FORMATION IN BACTERIA: STRUCTURAL BASISR01AI048689 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2001 to 2020
$7.6M
CHAPERONE-ASSISTED PILI ASSEMBLY IN PATHOGENIC E. COLIR01AI029549 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J., YUAN, PENG · 1991 to 2023
$5.7M
Pathogenic Fiber Formation in Bacteria: Structural BasisR37AI048689 · NIAID · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 2021 to 2026
$2.9M
BIOGENESIS AND INHIBITION OF BIOFILM-ASSOCIATED BACTERIAL AMYLOIDR01AI099099 · NIAID · WASHINGTON UNIVERSITY · PI FRIEDEN, CARL, HULTGREN, SCOTT J. · 2013 to 2017
$1.9M
NIAID NIH HHS R01 AI029549NIAID NIH HHS R01 AI048689NIAID NIH HHS R01 AI099099NIAID NIH HHS R37 AI048689NIAID NIH HHS U01 AI095542NIAID NIH HHS U01 AI095776NIDDK NIH HHS P50 DK064540NIDDK NIH HHS R01 DK051406
6 · The paper itself

Abstract

Urinary tract infections (UTIs) are common, and over half of women report having had at least one in their lifetime. Nearly a third of these women experience recurrent UTI episodes, but the mechanisms of these recurrences are not fully elucidated. Frequent use of antimicrobials for treatment and prevention of UTIs and other infections has contributed to the evolution of multidrug-resistant microorganisms globally. This is a looming worldwide crisis that has created an urgent need for novel strategies for the treatment and prevention of UTIs. Furthering our understanding of the mechanisms of recurrent UTIs, from both host and bacterial perspectives, will be paramount in developing targeted management strategies. In this review, we discuss recent findings regarding recurrent UTIs in women, including progress in our understanding of the mechanisms of recurrence as well as emerging treatments.

Indexed as

Urinary Tract InfectionsAnti-Bacterial AgentsHumansSecondary PreventionTreatment OutcomeUrodynamicsAnti-Bacterial Agents

Identifiers

PMID23832844
PMCPMC3797163
OpenAlexW2025302454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.