ArticleClinical & experimental metastasis2013
Electrochemotherapy is effective in the treatment of rat bone metastases.
Article in Clinical & experimental metastasis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- A Systematic Review about Imaging and Histopathological Findings for Detecting and Evaluating Electroporation Based Treatments Response.International journal of environmental research and public health · 2021Pooled it
- Electrochemotherapy in the Treatment of Bone Metastases: A Phase II Trial.World journal of surgery · 2016Trial
- Locoregional Treatment of Bone Metastases in a Lung Cancer Patient: A Case Report Using Multiple Techniques: Electrochemotherapy, Cryoablation, and Cementoplasty.Reports (MDPI) · 2026Article
- Electrochemotherapy in the Treatment of Bone Metastases: A Systematic Review.Journal of clinical medicine · 2023Review
- Optimization of Transpedicular Electrode Insertion for Electroporation-Based Treatments of Vertebral Tumors.Cancers · 2022Article
- Electrochemotherapy Is Effective in the Treatment of Bone Metastases.Current oncology (Toronto, Ont.) · 2022Article
- The Evidence of the Bystander Effect after Bleomycin Electrotransfer and Irreversible Electroporation.Molecules (Basel, Switzerland) · 2021Article
- Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2021Article
- Design and Characterization of a Minimally Invasive Bipolar Electrode for Electroporation.Biology · 2020Article
- Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome.Radiology and oncology · 2020Article
- Inhibitory effects of low intensity pulsed ultrasound on osteoclastogenesis induced in vitro by breast cancer cells.Journal of experimental & clinical cancer research : CR · 2018Article
- Electrochemotherapy as a New Modality in Interventional Oncology: A Review.Technology in cancer research & treatment · 2018Review
- Electrochemotherapy of Spinal Metastases Using Transpedicular Approach-A Numerical Feasibility Study.Technology in cancer research & treatment · 2018Article
- Minimally Invasive Electrochemotherapy Procedure for Treating Nasal Duct Tumors in Dogs using a Single Needle Electrode.Radiology and oncology · 2017Article
- Article
- Feasibility and safety of electrochemotherapy (ECT) in the pancreas: a pre-clinical investigation.Radiology and oncology · 2015Article
- Adjuvant TNF-α therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness.Radiology and oncology · 2015Article
- The surgical treatment of pelvic bone metastases.Advances in orthopedics · 2015Review
- Bone and soft tissue ablation.Seminars in interventional radiology · 2014Review
- Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cells.OncoimmunologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone metastases impair general health status, quality of life and survival of patients. Electrochemotherapy (ECT), which combines electroporation (EP) and the administration of anticancer drugs, has been recently introduced into clinical practice for the local treatment of solid tumours. In the present study, the ability of EP with bleomycin (Bleo) to induce MRMT-1 rat breast cancer cell death was investigated in vitro. Then, an in vivo model for bone metastases was set up by the inoculation of MRMT-1 cells in rat proximal tibia. 7 days after tumour induction the animals were treated with Bleo, EP, Bleo followed by EP (ECT), or left untreated. ECT eliminated the tumour in 6 out of 8 (75 %) treated metastases. Radiological evaluation showed that the Honore score in ECT-treated animals was significantly lower when compared with the other groups (p < 0.0005) and not significantly different from healthy controls. Bone morphology in ECT-treated animals, evaluated by histological and microtomographical analyses, showed intact cortical and trabecular bone structure with new bone apposition. Histomorphometric evaluation showed that ECT-treated metastases had significantly higher bone volume, trabecular number, trabecular thickness and bone mineral density compared with those of untreated metastases (respectively p < 0.0005 for BV/TV, Tb.N and BMD; p < 0.05 for Tb.Th) or metastases treated with Bleo (p < 0.05 for BV/TV, Tb.N, p < 0.005 for BMD) or EP (p < 0.005 for BV/TV, Tb.N; p < 0.0005 for BMD). These findings suggest that early ECT treatment of bone metastases is minimally invasive, safe and effective, thus providing pre-clinical evidence for its use in the treatment of human bone metastases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.