ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Influence of spontaneously occurring bursts of muscle sympathetic nerve activity on conduit artery diameter.
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Resting beat-to-beat blood pressure variability is preserved in young adults with major depressive disorder.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025Article
- Sympathetic baroreflex sensitivity is enhanced in postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Sympathetic transduction at rest and during cold pressor test in young healthy non-Hispanic Black and White women.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Acute changes in forearm vascular compliance during transient sympatho-excitation.Physiological reports · 2022Article
- Crossing the intersection of human hypertension and adrenergic vasoconstriction using innovative methods.Journal of human hypertension · 2022Article
- Sympathetic transduction in humans: recent advances and methodological considerations.American journal of physiology. Heart and circulatory physiology · 2021Review
- CORP: Standardizing methodology for assessing spontaneous baroreflex control of muscle sympathetic nerve activity in humans.American journal of physiology. Heart and circulatory physiology · 2021Article
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Sympathetic Transduction in Type 2 Diabetes Mellitus.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Regulation of regional cerebral blood flow during graded reflex-mediated sympathetic activation via lower body negative pressure.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety.Journal of neurophysiology · 2018Article
- Influence of physical inactivity on arterial compliance during a glucose challenge.Experimental physiology · 2018Article
- Exaggerated Vasoconstriction to Spontaneous Bursts of Muscle Sympathetic Nerve Activity in Healthy Young Black Men.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Sympathetic reactivity in young women with a family history of hypertension.American journal of physiology. Heart and circulatory physiology · 2015Article
- Characterizing rapid-onset vasodilation to single muscle contractions in the human leg.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Myogenic responses occur on a beat-to-beat basis in the resting human limb.American journal of physiology. Heart and circulatory physiology · 2015Article
- Muscle sympathetic nerve activity during cold stress and isometric exercise in healthy older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
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6 authors.
Funding
Abstract
Large increases in muscle sympathetic nerve activity (MSNA) can decrease the diameter of a conduit artery even in the presence of elevated blood pressure, suggesting that MSNA acts to regulate conduit artery tone. Whether this influence can be extrapolated to spontaneously occurring MSNA bursts has not been examined. Therefore, we tested the hypothesis that MSNA bursts decrease conduit artery diameter on a beat-by-beat basis during rest. Conduit artery responses were assessed in the brachial (BA), common femoral (CFA) and popliteal (PA) arteries to account for regional differences in vascular function. In 20 young men, MSNA, mean arterial pressure (MAP), conduit artery diameter, and shear rate (SR) were continuously measured during 20-min periods of supine rest. Spike-triggered averaging was used to characterize beat-by-beat changes in each variable for 15 cardiac cycles following all MSNA bursts, and a peak response was calculated. Diameter increased to a similar peak among the BA (+0.14 ± 0.02%), CFA (+0.17 ± 0.03%), and PA (+0.18 ± 0.03%) following MSNA bursts (all P < 0.05 vs. control). The diameter rise was positively associated with an increase in MAP in relation to increasing amplitude and consecutive numbers of MSNA bursts (P < 0.05). Such relationships were similar between arteries. SR changes following MSNA bursts were heterogeneous between arteries and did not appear to systematically alter diameter responses. Thus, in contrast to our hypothesis, spontaneously occurring MSNA bursts do not directly influence conduit arteries with local vasoconstriction or changes in shear, but rather induce a systemic pressor response that appears to passively increase conduit artery diameter.
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