ArticleDiabetologia2013
A population-based study of risk factors for severe hypoglycaemia in a contemporary cohort of childhood-onset type 1 diabetes.
Article in Diabetologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia.Frontiers in endocrinology · 2024Pooled it
- Dysglycemia among youth with type 1 diabetes and suboptimal glycemic control in the Flexible Lifestyle Empowering Change trial.Pediatric diabetes · 2019Trial
- Hypoglycemia-Associated EEG Changes in Prepubertal Children With Type 1 Diabetes.Journal of diabetes science and technology · 2016Trial
- Factors associated with nocturnal hypoglycemia in at-risk adolescents and young adults with type 1 diabetes.Diabetes technology & therapeutics · 2015Trial
- Explaining the Self-Care Behaviors in Type 2 Diabetic Patients Based on Adverse Childhood Experiences, Subjective Socioeconomic Status, and Mindfulness in Isfahan, Iran.Health science reports · 2025Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- 14. Children and Adolescents: Standards of Care in Diabetes-2024.Diabetes care · 2024Review
- Close intervention sessions complement intensive insulin therapy in paediatric diabetes: a longitudinal study.Archives of disease in childhood · 2023Article
- Article
- Managing Severe Hypoglycaemia in Patients with Diabetes: Current Challenges and Emerging Therapies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- 14. Children and Adolescents: Standards of Care in Diabetes-2023.Diabetes care · 2023Review
- ISPAD Clinical Practice Consensus Guidelines 2022: Assessment and management of hypoglycemia in children and adolescents with diabetes.Pediatric diabetes · 2022Article
- Article
- Factors related to glycemic control in children and adolescents with type 1 diabetes mellitus in Isfahan, Iran.Journal of diabetes and metabolic disorders · 2021Article
- Felix dies natalis, insulin… ceterum autem censeo "beta is better".Acta diabetologica · 2021Review
- The Evolution of Hemoglobin ADiabetes care · 2021Review
- Hemoglobin A1c Trajectory in Pediatric Patients with Newly Diagnosed Type 1 Diabetes.Diabetes technology & therapeutics · 2019Article
- Insulin pump initiation and education for children and adolescents - a qualitative study of current practice in New Zealand.Journal of diabetes and metabolic disorders · 2019Article
- Diabetes in Childhood and Adolescence.Deutsches Arzteblatt international · 2018Review
- Severe hypoglycemia rates are not associated with HbA1c: a cross-sectional analysis of 3 contemporary pediatric diabetes registry databases.Pediatric diabetes · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisSevere hypoglycaemia is a major barrier to optimising glycaemic control. Recent changes in therapy, however, may have altered the epidemiology of severe hypoglycaemia and its associated risk factors. The aim of this study was to examine the incidence rates and risk factors associated with severe hypoglycaemia in a contemporary cohort of children and adolescents with type 1 diabetes.
methodsSubjects were identified from a population-based register containing data on >99% of patients (<16 years of age) who were being treated for type 1 diabetes in Western Australia. Patients attend the clinic approximately every 3 months, where data pertaining to diabetes management, demographics and complications including hypoglycaemia are prospectively recorded. A severe hypoglycaemic event was defined as an episode of coma or convulsion associated with hypoglycaemia. Risk factors assessed included age, duration of diabetes, glycaemic control, sex, insulin therapy, socioeconomic status and calendar year.
resultsClinical visit data from 1,770 patients, providing 8,214 patient-years of data between 2000 and 2011 were analysed. During follow-up, 841 episodes of severe hypoglycaemia were observed. No difference in risk of severe hypoglycaemia was observed between age groups. Good glycaemic control (HbA1c <7% [53 mmol/mol]) compared with the cohort average (HbA1c 8-9% [64-75 mmol/mol]) was not associated with an increased risk of severe hypoglycaemia. When compared with patients on injection regimens, subjects aged 12-18 years on pump therapy were at reduced risk of severe hypoglycaemia (incidence risk ratio 0.6; 95% CI 0.4, 0.9). CONCLUSIONS/
interpretationIn this population-based sample of children and adolescents with type 1 diabetes, contemporary therapy is associated with a changed pattern and incidence of severe hypoglycaemia.
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