ArticleJournal of neuroscience methods2013
Automating ultrasonic vocalization analyses: the WAAVES program.
Article in Journal of neuroscience methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Sex- and Lineage-Dependent Transgenerational Effects of Vinclozolin and Flutamide on Rat Development and Behavior.Journal of the Endocrine Society · 2026Article
- Ultrasonic vocalisations in the Flinders Sensitive Line rat, a genetic animal model of depression.Acta neuropsychiatrica · 2025Article
- Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents.Molecular autism · 2022Review
- TrackUSF, a novel tool for automated ultrasonic vocalization analysis, reveals modified calls in a rat model of autism.BMC biology · 2022Article
- Nucleus Accumbens Chemogenetic Inhibition Suppresses Amphetamine-Induced Ultrasonic Vocalizations in Male and Female Rats.Brain sciences · 2021Article
- Effects of Ethanol Exposure during Lactation on Ultrasonic Vocalizations of Rat Pups upon Their Isolation: Increase in Pup Distress Calls.Brain sciences · 2021Article
- Acoustilytix™: A Web-Based Automated Ultrasonic Vocalization Scoring Platform.Brain sciences · 2021Article
- Automatic classification of mice vocalizations using Machine Learning techniques and Convolutional Neural Networks.PloS one · 2021Article
- Spontaneous Ultrasonic Vocalization Transmission in Adult, Male Long-Evans Rats Is Age-Dependent and Sensitive to EtOH Modulation.Brain sciences · 2020Article
- Stroking stimulation of the skin elicits 50-kHz ultrasonic vocalizations in young adult rats.The journal of physiological sciences : JPS · 2020Article
- Sex-specific ultrasonic vocalization patterns and alcohol consumption in high alcohol-drinking (HAD-1) rats.Physiology & behavior · 2019Article
- DeepSqueak: a deep learning-based system for detection and analysis of ultrasonic vocalizations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats.Environmental health perspectives · 2018Article
- Alcohol-naïve USVs distinguish male HAD-1 from LAD-1 rat strains.Alcohol (Fayetteville, N.Y.) · 2018Article
- Rodent ultrasonic vocalizations as biomarkers of future alcohol use: A predictive analytic approach.Cognitive, affective & behavioral neuroscience · 2018Article
- Negative Affect-Associated USV Acoustic Characteristics Predict Future Excessive Alcohol Drinking and Alcohol Avoidance in Male P and NP Rats.Alcoholism, clinical and experimental research · 2017Article
- Alcohol enhances unprovoked 22-28 kHz USVs and suppresses USV mean frequency in High Alcohol Drinking (HAD-1) male rats.Behavioural brain research · 2016Article
- Ultrasonic vocalization in rats self-administering heroin and cocaine in different settings: evidence of substance-specific interactions between drug and setting.Psychopharmacology · 2016Article
- Amygdalar Auditory Neurons Contribute to Self-Other Distinction during Ultrasonic Social Vocalization in Rats.Frontiers in neuroscience · 2016Article
- Alcohol-preferring P rats emit spontaneous 22-28 kHz ultrasonic vocalizations that are altered by acute and chronic alcohol experience.Alcoholism, clinical and experimental research · 2015Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundHuman emotion is a crucial component of drug abuse and addiction. Ultrasonic vocalizations (USVs) elicited by rodents are a highly translational animal model of emotion in drug abuse studies. A major roadblock to comprehensive use of USV data is the overwhelming burden to attain accurate USV assessment in a timely manner. One of the most accurate methods of analyzing USVs, human auditory detection with simultaneous spectrogram inspection, requires USV sound files to be played back 4% normal speed. NEW
methodWAAVES (WAV-file Automated Analysis of Vocalizations Environment Specific) is an automated USV assessment program utilizing MATLAB's Signal and Image Processing Toolboxes in conjunction with a series of customized filters to separate USV calls from background noise, and accurately tabulate and categorize USVs as flat or frequency-modulated (FM) calls. In the current report, WAAVES functionality is demonstrated by USV analyses of cocaine self-administration data collected over 10 daily sessions.
resultsWAAVES counts are significantly correlated with human auditory counts (r(48)=0.9925; p<0.001). Statistical analyses used WAAVES output to examine individual differences in USV responses to cocaine, cocaine-associated cues and relationships between USVs, cocaine intake and locomotor activity. COMPARISON WITH EXISTING
methodWAAVES output is highly accurate and provides tabulated data in approximately 0.3% of the time required when using human auditory detection methods.
conclusionsThe development of a customized USV analysis program, such as WAAVES streamlines USV assessment and enhances the ability to utilize USVs as a tool to advance drug abuse research and ultimately develop effective treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.