ArticleOsteoarthritis and cartilage2013
Physical activity in relation to knee cartilage T2 progression measured with 3 T MRI over a period of 4 years: data from the Osteoarthritis Initiative.
Article in Osteoarthritis and cartilage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Immediate and Delayed Effects of Joint Loading Activities on Knee and Hip Cartilage: A Systematic Review and Meta-analysis.Sports medicine - open · 2023Pooled it
- Recreational Physical Activity and Risk of Incident Knee Osteoarthritis: An International Meta-Analysis of Individual Participant-Level Data.Arthritis & rheumatology (Hoboken, N.J.) · 2022Pooled it
- Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review.Medicine and science in sports and exercise · 2019Pooled it
- Barriers and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence.BMJ open · 2017Pooled it
- Cartilage tissue turnover increases with high- compared to low-intensity resistance training in patients with knee OA.Arthritis research & therapy · 2023Trial
- The 6-m timed hop test is a prognostic factor for outcomes in patients with meniscal tears treated with exercise therapy or arthroscopic partial meniscectomy: a secondary, exploratory analysis of the Odense-Oslo meniscectomy versus exercise (OMEX) trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Trial
- Associations Between Patient Characteristics and Cartilage T1ρ Relaxation Times Vary Over Time Following Patellar Dislocation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Physical activity and joint health: Implications for knee osteoarthritis disease pathophysiology and mechanics.Experimental physiology · 2026Review
- Which matters more for preventing knee replacements: reducing overactivity or combating inactivity?Aging clinical and experimental research · 2026Article
- Temporal Patterns of Wearable Accelerometer-Measured Physical Activity and Symptom Worsening in Knee Osteoarthritis: A 2-Year Longitudinal Study from the Osteoarthritis Initiative.Sensors (Basel, Switzerland) · 2026Article
- Are Changes in Physical Activity, Pain, and Quality of Life in Patients with Knee Osteoarthritis After Exercise Therapy and Education Beyond Normal Fluctuations? A Comparative Study.Journal of clinical medicine · 2025Article
- Patellofemoral Cartilage Degradation Based on T1ρ Relaxation Times Varies Inversely With BMI After Patellar Dislocation.Orthopaedic journal of sports medicine · 2025Article
- Article
- Walking recovers cartilage compressive strain in vivo.Osteoarthritis and cartilage open · 2024Article
- Quantitative Evaluation of Knee Cartilage in Professional Martial Arts Athletes Using T2 Mapping: A Comparative Study.Journal of athletic training · 2024Article
- Cartilage compositional MRI-a narrative review of technical development and clinical applications over the past three decades.Skeletal radiology · 2024Review
- Compositional MR imaging of cartilage and joint mechanics.Osteoarthritis imaging · 2024Article
- Weight-Bearing Physical Activity, Lower-Limb Muscle Mass, and Risk of Knee Osteoarthritis.JAMA network open · 2024Article
- Investigating the causal relationship between physical activity and incident knee osteoarthritis: a two-sample Mendelian randomization study.Scientific reports · 2024Article
- MRI-based TSkeletal radiology · 2023Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe purpose of this study was to analyze the longitudinal association between physical activity levels and early degenerative cartilage changes in the knee, measured using T2 relaxation times over a period of 4 years in individuals without clinical or radiographic evidence of OA.
designCartilage T2 was measured at baseline and after 2 and 4 years in 205 subjects aged 45-60 years from the Osteoarthritis Initiative (OAI) incidence and normal cohorts with no knee pain (Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score of zero), and a Kellgren Lawrence (KL) score of <2 at baseline. Physical activity was scored using the Physical Activity Scale for the Elderly (PASE) questionnaire, which was obtained yearly over 4 years. The relationship between physical activity and T2 was studied using a mixed model linear regression, including random effects, and adjusted for age, sex, and body mass index (BMI).
resultsT2 values for all PASE tertiles progressed over the 4-year period. T2 progression was increased in the highest tertile of physical activity compared to the mid-tertile at the medial tibia (MT) (P = 0.041), patella (Pat) (P = 0.019), and average T2 of all knee compartments combined (P = 0.033). Subjects with the lowest 15% PASE scores showed significantly higher T2 progression compared to the mid-level physical activity group at the lateral femur (LF) (P = 0.025), lateral tibia (LT) (P = 0.043), medial femur (MF) (P = 0.044), tibiofemoral compartment (P = 0.017), patellofemoral compartment (P = 0.016), lateral compartments (P = 0.003), and average of all compartments (P = 0.043).
conclusionHigh and very low PASE scores were associated with greater progression of cartilage T2 measurements in asymptomatic, middle-aged individuals, suggesting accelerated cartilage matrix biochemical degeneration over time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.