ArticleJournal of theoretical biology2013
A model for intracellular actin waves explored by nonlinear local perturbation analysis.
Article in Journal of theoretical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Actin network heterogeneity tunes activator-inhibitor dynamics at the cell cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Spots, stripes, and spiral waves in models for static and motile cells : GTPase patterns in cells.Journal of mathematical biology · 2021Article
- Membrane Tension Can Enhance Adaptation to Maintain Polarity of Migrating Cells.Biophysical journal · 2020Article
- Article
- Tuning Cell Motility via Cell Tension with a Mechanochemical Cell Migration Model.Biophysical journal · 2020Article
- Simple Rho GTPase Dynamics Generate a Complex Regulatory Landscape Associated with Cell Shape.Biophysical journal · 2020Article
- Correlated random walks inside a cell: actin branching and microtubule dynamics.Journal of mathematical biology · 2019Article
- Computational modeling of single-cell mechanics and cytoskeletal mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles.Nature communications · 2017Article
- A mathematical model coupling polarity signaling to cell adhesion explains diverse cell migration patterns.PLoS computational biology · 2017Article
- Local perturbation analysis: a computational tool for biophysical reaction-diffusion models.Biophysical journal · 2015Article
- Dynamics of actin waves on patterned substrates: a quantitative analysis of circular dorsal ruffles.PloS one · 2015Article
- An efficient, nonlinear stability analysis for detecting pattern formation in reaction diffusion systems.Bulletin of mathematical biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Waves and dynamic patterns in chemical and physical systems have long interested experimentalists and theoreticians alike. Here we investigate a recent example within the context of cell biology, where waves of actin (a major component of the cytoskeleton) and its regulators (nucleation promoting factors, NPFs) are observed experimentally. We describe and analyze a minimal reaction diffusion model depicting the feedback between signalling proteins and filamentous actin (F-actin). Using numerical simulation, we show that this model displays a rich variety of patterning regimes. A relatively recent nonlinear stability method, the Local Perturbation Analysis (LPA), is used to map the parameter space of this model and explain the genesis of patterns in various linear and nonlinear patterning regimes. We compare our model for actin waves to others in the literature, and focus on transitions between static polarization, transient waves, periodic wave trains, and reflecting waves. We show, using LPA, that the spatially distributed model gives rise to dynamics that are absent in the kinetics alone. Finally, we show that the width and speed of the waves depend counter-intuitively on parameters such as rates of NPF activation, negative feedback, and the F-actin time scale.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.