ReviewGene2013
A current review of molecular mechanisms regarding osteoarthritis and pain.
Review in Gene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
180 citing papers in PubMed, 3 syntheses or guidelines pooled it, 411 citations in OpenAlex.
- A bibliometric analysis of studies related to the nuclear factor kappa B signaling pathway in knee osteoarthritis between 2004 and 2023.Frontiers in medicine · 2025Pooled it
- A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis.Advances in experimental medicine and biology · 2021Pooled it
- The -1082A>G polymorphism in promoter region of interleukin-10 and risk of digestive cancer: a meta-analysis.Scientific reports · 2014Pooled it
- Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial.Nature medicine · 2023Trial
- Human synovial fluid interleukin-6, but not type II collagen breakdown, positively correlated with pain after anterior cruciate ligament injury and reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Trial
- Effect of Resveratrol on Serum Levels of Type II Collagen and Aggrecan in Patients with Knee Osteoarthritis: A Pilot Clinical Study.BioMed research international · 2021Trial
- Assessing adverse effects of intra-articular botulinum toxin A in healthy Beagle dogs: A placebo-controlled, blinded, randomized trial.PloS one · 2018Trial
- Trial
- The effect of intra-articular botulinum toxin A on substance P, prostaglandin EBMC veterinary research · 2017Trial
- Geroprotective efficacy of Triphalaguggul: a polyherbal formulation against inflammatory disorders through inhibition of pro-inflammatory cytokines as therapeutic biomarkers.Biogerontology · 2026Article
- Short- and long-term effects of dronedarone on Cav3.1- and Cav3.2-T-type calcium channel current.European journal of histochemistry : EJH · 2026Article
- Qualitative and Quantitative Evaluation of Loose Bodies as a Novel Cell Source for Autologous Chondrocyte Implantation.Orthopaedic journal of sports medicine · 2026Article
- Metabolic reprogramming in polyol pathway contributes to anti-inflammatory effect of glucosamine salts on synovial fibroblasts.npj metabolic health and disease · 2026Article
- Clinical and Biochemical Effects of Intra-Articular Autologous Conditioned Serum and Triamcinolone in an Equine Model of Synovitis.Animals : an open access journal from MDPI · 2026Article
- Exploring senescence markers as potential drivers of osteoarthritis pain in aging adults.Experimental gerontology · 2025Review
- Regenerative Medicine: The Next Generation of Autologous Blood Formulations.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025Review
- Association betweensubchondral bone sclerosis and pain in varus ankle osteoarthritis: a CT-based analysis using patient-reported outcomes.Archives of orthopaedic and trauma surgery · 2025Article
- The Role of Home-Based Exercise in Managing Common Musculoskeletal Disorders: A Narrative Review.Journal of functional morphology and kinesiology · 2025Review
- Article
- Study of Retinoic Acid-Induced Osteoarthritis: Integrating RNA-Sequencing, Network Pharmacology, Molecular Docking, and Experimental Validation.International journal of molecular sciences · 2025Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of life and increased health costs. To understand this disease, physicians have been studying risk factors, such as genetic predisposition, aging, obesity, and joint malalignment; however have been unable to conclusively determine the direct etiology. Current treatment options are short-term or ineffective and fail to address pathophysiological and biochemical mechanisms involved with cartilage degeneration and the induction of pain in arthritic joints. OA pain involves a complex integration of sensory, affective, and cognitive processes that integrate a variety of abnormal cellular mechanisms at both peripheral and central (spinal and supraspinal) levels of the nervous system Through studies examined by investigators, the role of growth factors and cytokines has increasingly become more relevant in examining their effects on articular cartilage homeostasis and the development of osteoarthritis and osteoarthritis-associated pain. Catabolic factors involved in both cartilage degradation in vitro and nociceptive stimulation include IL-1, IL-6, TNF-α, PGE2, FGF-2 and PKCδ, and pharmacologic inhibitors to these mediators, as well as compounds such as RSV and LfcinB, may potentially be used as biological treatments in the future. This review explores several biochemical mediators involved in OA and pain, and provides a framework for the understanding of potential biologic therapies in the treatment of degenerative joint disease in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.