ArticleNeuron2013
Intersecting circuits generate precisely patterned retinal waves.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- A toolbox for navigating and analyzing the spatiotemporal properties of retinal waves.bioRxiv : the preprint server for biology · 2025Article
- Retinal ganglion cells encode the direction of motion outside their classical receptive field.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mapping the Retina onto the Brain.Cold Spring Harbor perspectives in biology · 2024Review
- Functional maturation of the rod bipolar to AII-amacrine cell ribbon synapse in the mouse retina.Cell reports · 2023Article
- Acetylcholine Promotes Directionally Biased Glutamatergic Retinal Waves.bioRxiv : the preprint server for biology · 2023Article
- Retinal waves prime visual motion detection by simulating future optic flow.Science (New York, N.Y.) · 2021Article
- Synaptic repair and vision restoration in advanced degenerating eyes by transplantation of retinal progenitor cells.Stem cell reports · 2021Article
- Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems.Genes & development · 2021Review
- Müller Glia in Retinal Development: From Specification to Circuit Integration.Frontiers in neural circuits · 2021Review
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- Spontaneous Retinal Waves Can Generate Long-Range Horizontal Connectivity in Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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- Distinct Developmental Mechanisms Act Independently to Shape Biased Synaptic Divergence from an Inhibitory Neuron.Current biology : CB · 2020Article
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- Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors.Cell reports · 2019Article
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- Electrical synapses convey orientation selectivity in the mouse retina.Nature communications · 2017Article
- Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks.PLoS computational biology · 2017Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The developing retina generates spontaneous glutamatergic (stage III) waves of activity that sequentially recruit neighboring ganglion cells with opposite light responses (ON and OFF RGCs). This activity pattern is thought to help establish parallel ON and OFF pathways in downstream visual areas. The circuits that produce stage III waves and desynchronize ON and OFF RGC firing remain obscure. Using dual patch-clamp recordings, we find that ON and OFF RGCs receive sequential excitatory input from ON and OFF cone bipolar cells (CBCs), respectively. This input sequence is generated by crossover circuits, in which ON CBCs control glutamate release from OFF CBCs via diffusely stratified inhibitory amacrine cells. In addition, neighboring ON CBCs communicate directly and indirectly through lateral glutamatergic transmission and gap junctions, both of which are required for wave initiation and propagation. Thus, intersecting lateral excitatory and vertical inhibitory circuits give rise to precisely patterned stage III retinal waves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.