ArticleSchizophrenia research2013
Intracortical excitatory and thalamocortical boutons are intact in primary auditory cortex in schizophrenia.
Article in Schizophrenia research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Altered Molecular Composition of a Specific Subset of Prefrontal Cortical Excitatory Synapses in Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Terminal type-specific cannabinoid CB1 receptor alterations in patients with schizophrenia: A pilot study.Neurobiology of disease · 2023Article
- Terminal type-specific cannabinoid CB1 receptor alterations in patients with schizophrenia: a pilot study.bioRxiv : the preprint server for biology · 2023Article
- Vesicular Glutamate Transporter Changes in the Cortical Default Mode Network During the Clinical and Pathological Progression of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Unusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia.Biological psychiatry · 2022Review
- Cell type specific cannabinoid CB1 receptor distribution across the human and non-human primate cortex.Scientific reports · 2022Article
- Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research.Frontiers in molecular neuroscience · 2021Review
- GABA bouton subpopulations in the human dentate gyrus are differentially altered in mesial temporal lobe epilepsy.Journal of neurophysiology · 2020Article
- Synaptic Proteome Alterations in the Primary Auditory Cortex of Individuals With Schizophrenia.JAMA psychiatry · 2020Article
- Selective Loss of Smaller Spines in Schizophrenia.The American journal of psychiatry · 2017Article
- Stereological Assessments of Neuronal Pathology in Auditory Cortex in Schizophrenia.Frontiers in neuroanatomy · 2017Review
- Thalamocortical-auditory network alterations following cuprizone-induced demyelination.Journal of neuroinflammation · 2016Article
- Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysis.Arthritis research & therapy · 2016Article
- Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia.Biological psychiatry · 2015Article
- Auditory dysfunction in schizophrenia: integrating clinical and basic features.Nature reviews. Neuroscience · 2015Review
- Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.Biological psychiatry · 2015Article
- The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies.Annals of the New York Academy of Sciences · 2015Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
Schizophrenia is associated with auditory processing impairments that could arise as a result of primary auditory cortex excitatory circuit pathology. We have previously reported a deficit in dendritic spine density in deep layer 3 of primary auditory cortex in subjects with schizophrenia. As boutons and spines can be structurally and functionally co-regulated, we asked whether the densities of intracortical excitatory or thalamocortical presynaptic boutons are also reduced. We studied 2 cohorts of subjects with schizophrenia and matched controls, comprising 27 subject pairs, and assessed the density, number, and within-bouton vesicular glutamate transporter (VGluT) protein level of intracortical excitatory (VGluT1-immunoreactive) and thalamocortical (VGluT2-immunoreactive) boutons in deep layer 3 of primary auditory cortex using quantitative confocal microscopy and stereologic sampling methods. We found that VGluT1- and VGluT2-immunoreactive puncta densities and numbers were not altered in deep layer 3 of primary auditory cortex of subjects with schizophrenia. Our results indicate that reduced dendritic spine density in primary auditory cortex of subjects with schizophrenia is not matched by a corresponding reduction in excitatory bouton density. This suggests excitatory boutons in primary auditory cortex in schizophrenia may synapse with structures other than spines, such as dendritic shafts, with greater frequency. The discrepancy between dendritic spine reduction and excitatory bouton preservation may contribute to functional impairments of the primary auditory cortex in subjects with schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.