Evidence map›Paper›PMID 23830640›Full record

ReviewTrends in biochemical sciences2013

The differences between ICL repair during and outside of S phase.

Hannah L Williams, Max E Gottesman, Jean Gautier

Open access · greenAbstract readComparative StudyReview
In one paragraph

Review in Trends in biochemical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 56 citations in OpenAlex.

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  15. Fanconi anemia-independent DNA inter-strand crosslink repair in eukaryotes.Progress in biophysics and molecular biology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hannah L WilliamsDepartment of Genetics and Development, Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
Max E Gottesman
Jean Gautier
Columbia University · USCancer Genetics (United States) · US

Funding

Regulation of the DNA damage response by the MRN-ATM pathwayR01CA092245 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GAUTIER, JEAN · 2002 to 2015
$4.0M
Studies of DNA interstrand crosslink repair to improve crosslinking drug therapieR01CA167826 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GAUTIER, JEAN · 2012 to 2015
$1.3M
NCI NIH HHS CA167826NCI NIH HHS CA92245NCI NIH HHS R01 CA092245NCI NIH HHS R01 CA167826
6 · The paper itself

Abstract

DNA interstrand crosslinks (ICLs) are complex lesions that block essential DNA transactions including DNA replication, recombination, and RNA transcription. Naturally occurring ICLs are rare, yet these lesions are the major cause of toxicity following treatment with several classes of crosslinking cancer chemotherapeutic drugs. ICLs are repaired during and outside of S phase by pathways with overlapping as well as distinct features. Here, we discuss some recent insights into the mechanisms of replication-dependent and replication-independent repair of ICLs with special emphasis on the differences between these repair pathways.

Indexed as

DNA DamageDNA RepairModels, BiologicalS PhaseAnimalsAntineoplastic AgentsCell CycleCross-Linking ReagentsDNA Repair EnzymesHumansRecombinational DNA RepairAntineoplastic AgentsCross-Linking ReagentsDNA Repair Enzymes

Identifiers

PMID23830640
PMCPMC3763924
OpenAlexW2034905942

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.