ArticleMethods in enzymology2013
Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates.
Article in Methods in enzymology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Lipid Peroxidation-Related Redox Signaling in Osteosarcoma.International journal of molecular sciences · 2024Review
- Overoxidation and Oligomerization ofPathogens (Basel, Switzerland) · 2023Article
- Native state fluctuations in a peroxiredoxin active site match motions needed for catalysis.Structure (London, England : 1993) · 2022Article
- Bioinformatic Analyses of Peroxiredoxins and RF-Prx: A Random Forest-Based Predictor and Classifier for Prxs.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Dynamics of a Key Conformational Transition in the Mechanism of Peroxiredoxin Sulfinylation.ACS catalysis · 2020Article
- The bicarbonate/carbon dioxide pair increases hydrogen peroxide-mediated hyperoxidation of human peroxiredoxin 1.The Journal of biological chemistry · 2019Article
- Unraveling the effects of peroxiredoxin 2 nitration; role of C-terminal tyrosine 193.Free radical biology & medicine · 2019Article
- Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.The Journal of biological chemistry · 2018Article
- Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Peroxiredoxin Catalysis at Atomic Resolution.Structure (London, England : 1993) · 2016Article
- Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation.The Biochemical journal · 2016Article
- Kinetic Approaches to Measuring Peroxiredoxin Reactivity.Molecules and cells · 2016Review
- Utilizing Natural and Engineered Peroxiredoxins As Intracellular Peroxide Reporters.Molecules and cells · 2016Review
- A Kinetic Platform to Determine the Fate of Hydrogen Peroxide in Escherichia coli.PLoS computational biology · 2015Article
- Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling.Trends in biochemical sciences · 2015Review
- Mass spectrometry in studies of protein thiol chemistry and signaling: opportunities and caveats.Free radical biology & medicine · 2015Review
- A primer on peroxiredoxin biochemistry.Free radical biology & medicine · 2015Review
- Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC.Biochemistry · 2015Article
- Tuning of peroxiredoxin catalysis for various physiological roles.Biochemistry · 2014Review
- Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase.The Journal of biological chemistry · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Peroxiredoxins (Prxs) not only are very effective peroxide-reducing enzymes but also are susceptible to being oxidatively inactivated by their own substrates. The level of sensitivity to such hyperoxidation varies depending on both the enzyme involved and the type of peroxide substrate. For some Prxs, the hyperoxidation has physiological relevance, so it is important to define approaches that can be used to quantify sensitivity. Here, we describe three distinct approaches that can be used to obtain quantitative or semiquantitative estimates of Prx sensitivity and define C(hyp1%) as a simple way of quantifying sensitivity so that values can easily be compared.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.