ArticleAmerican journal of human genetics2013
Identification of multiple genetic susceptibility loci in Takayasu arteritis.
Article in American journal of human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 6 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 6 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- Surgical Management of Aortic Regurgitation in Takayasu's Arteritis: A Systematic Review of Techniques and Outcomes.The Permanente journal · 2022Pooled it
- Cross-phenotype analysis of Immunochip data identifiesAnnals of the rheumatic diseases · 2018Pooled it
- Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy.Scientific reports · 2017Pooled it
- Relationship of HLA-B*51 and HLA-B*52 alleles and TNF-α-308A/G polymorphism with susceptibility to Takayasu arteritis: a meta-analysis.Clinical rheumatology · 2017Pooled it
- Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.Annals of the rheumatic diseases · 2016Pooled it
- Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation.Arthritis research & therapy · 2015Pooled it
- Takayasu Arteritis and Giant Cell Arteritis: Results From a Cross-Sectional Study of 96 Italian Patients.Immunity, inflammation and disease · 2026Article
- Biomarkers in Primary Systemic Vasculitides: Narrative Review.International journal of molecular sciences · 2026Review
- Advances in the pathophysiology, diagnosis and treatment of Takayasu arteritis.Nature reviews. Rheumatology · 2025Review
- Functional and Practical Insights Into the Genetic Basis of Takayasu Arteritis.ACR open rheumatology · 2025Review
- Exploring the causal relationship between Takayasu arteritis and inflammatory bowel disease using Mendelian randomization.Immunologic research · 2024Article
- A Glimpse into Humoral Response and Related Therapeutic Approaches of Takayasu's Arteritis.International journal of molecular sciences · 2024Review
- Frequency and the effects of spondyloarthritis-spectrum disorders on the clinical course and management of Takayasu arteritis: an observational retrospective study.Clinical rheumatology · 2024Observational
- LanDis: the disease landscape explorer.European journal of human genetics : EJHG · 2024Article
- Anti-integrin αvβ6 antibody in Takayasu arteritis patients with or without ulcerative colitis.Frontiers in immunology · 2024Article
- A retrospective study of infantile-onset Takayasu arteritis: experience from a tertiary referral center in China.Frontiers in cardiovascular medicine · 2024Article
- Benign disorders of the mediastinum: a narrative review.Mediastinum (Hong Kong, China) · 2024Review
- Successful Use of Tofacitinib in Refractory Takayasu Arteritis: A Case Series.Mediterranean journal of rheumatology · 2023Article
- Pathophysiology, Diagnosis, and Management of Takayasu Arteritis: A Review of Current Advances.Cureus · 2023Review
- Animal models for large vessel vasculitis - The unmet need.Rheumatology and immunology research · 2023Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
44 authors at 20 institutions in 3 countries.
Funding
Abstract
Takayasu arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is supported by the genetic association with HLA-B*52. We genotyped ~200,000 genetic variants in two ethnically divergent Takayasu arteritis cohorts from Turkey and North America by using a custom-designed genotyping platform (Immunochip). Additional genetic variants and the classical HLA alleles were imputed and analyzed. We identified and confirmed two independent susceptibility loci within the HLA region (r(2) < 0.2): HLA-B/MICA (rs12524487, OR = 3.29, p = 5.57 × 10(-16)) and HLA-DQB1/HLA-DRB1 (rs113452171, OR = 2.34, p = 3.74 × 10(-9); and rs189754752, OR = 2.47, p = 4.22 × 10(-9)). In addition, we identified and confirmed a genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus on chromosome 1 (rs10919543, OR = 1.81, p = 5.89 × 10(-12)). The risk allele in this locus results in increased mRNA expression of FCGR2A. We also established the genetic association between IL12B and Takayasu arteritis (rs56167332, OR = 1.54, p = 2.18 × 10(-8)).
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