ArticleBMC complementary and alternative medicine2013
The in vitro antisickling and antioxidant effects of aqueous extracts Zanthoxyllum heitzii on sickle cell disorder.
Article in BMC complementary and alternative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 89 citations in OpenAlex.
- Review
- In vitro study of anti-sickling effects of aqueous extracts of Garcinia kola (seeds), Zingiber officinale (rhizomes) and Allium sativum(bulbs) on sodium metabisulphite-treated HBSS erythrocytes.BMC complementary medicine and therapies · 2025Article
- Effect of Heat-Assisted and Ultrasound-Assisted Extraction Methods on the Phenolic Profile and Biological Activity ofAntioxidants (Basel, Switzerland) · 2025Article
- Sickle Cell Disease: Current Drug Treatments and Functional Foods with Therapeutic Potential.Current issues in molecular biology · 2024Review
- Comparative antisickling and antioxidant activities ofRSC advances · 2023Article
- Upcycling Quince Peel into Bioactive Ingredients and Fiber Concentrates through Multicomponent Extraction Processes.Antioxidants (Basel, Switzerland) · 2023Article
- Can Crude Oil Exploration Influence the Phytochemicals and Bioactivity of Medicinal Plants? A Case of NigerianMolecules (Basel, Switzerland) · 2022Article
- Natural Antioxidants in Anemia Treatment.International journal of molecular sciences · 2021Review
- Smartphone-based sickle cell disease detection and monitoring for point-of-care settings.Biosensors & bioelectronics · 2020Article
- Phenolic Compounds from Water-Ethanol Extracts ofTheScientificWorldJournal · 2019Article
- Adaptation of a microbead assay for the easy evaluation of traditional anti-sickling medicines: application to DREPANOSTAT and FACA.Pharmaceutical biology · 2018Article
- Complementary and alternative medicine use in thalassemia patients in Shiraz, southern Iran: A cross-sectional study.Journal of traditional and complementary medicine · 2018Article
- Hypoxia-enhanced adhesion of red blood cells in microscale flow.Microcirculation (New York, N.Y. : 1994) · 2017Article
- Potential of Three Ethnomedicinal Plants as Antisickling Agents.Molecular pharmaceutics · 2017Article
- Article
- In vitro organo-protective effect of bark extracts from Syzygium guineense var macrocarpum against ferric-nitrilotriacetate-induced stress in wistar rats homogenates.BMC complementary and alternative medicine · 2016Article
- Application of a cell microarray chip system for accurate, highly sensitive, and rapid diagnosis for malaria in Uganda.Scientific reports · 2016Article
- Oxidative profile of sickle cell patients in a Cameroonian urban hospital.BMC clinical pathology · 2016Article
- Antisickling and toxicological evaluation of the leaves of Scoparia dulcis Linn (Scrophulariaceae).BMC complementary and alternative medicine · 2015Article
- Identification of chemical constituents of Zanthoxylum heitzii stem bark and their insecticidal activity against the malaria mosquito Anopheles gambiae.Parasites & vectors · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral plant extracts from Rutaceae family are currently used to the management of sickle cell disorder (SCD) in the African. Few reports have shown that extracts from Zanthoxyllum or Fagara genus demonstrated anti-sickling property. This study investigates the in vitro antisickling and antioxidant properties of extracts from Zanthoxyllum heitzii.
methodsThe sickling of red blood cells (RBCs) was induced using sodium metabisulfite (2%) followed by treatment with extracts at different concentrations. The osmotic fragility tests permits to explore the effect of Z. heitzii extracts on haemoglobin S solubility and sickle cells membrane stability. For each extract, qualitative phytochemical tests were used to identify the presence of alkaloids, tannins, saponins, flavonoids, glycosides and phenols, while some quantitative methods such as Folin, Ferric Reducing Antioxidant Power (FRAP) and diphenyl 1, 2 picryl hydrazyl (DPPH) were used to determine the antioxidant potential of these extracts.
resultsSodium metabisulphite increased the sickling of RBCs from 29.62 to 55.46% during 2 h. Treatment of sickling cells with extracts at different concentrations showed that a decrease of the percentage of sickling cells was found in both induced and non induced sickling cells. The fruits extract of Z. heitzii demonstrated the best anti-sickling property. The same extract at 250 μg/mL showed the best membrane cell stability compared to others. All the extracts revealed an antioxidant and anti-radical activities although lesser compared to the standard.
conclusionThe fruit extract of Z. Heitzii demonstrated the most significant antisickling effect with a potential for use in the clinical management of SCD.
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