ArticleACS nano2013
Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer.
Article in ACS nano, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 269 citations in OpenAlex.
- Semisynthetic Ferritin Nanocages for Flexible, Site-Specific Targeting and Ligand-Free Activation of Membrane Receptors.Nano letters · 2025Article
- Multifunctional vesicles in cancer therapy and theranostics: current advances and future challenges.Journal of nanobiotechnology · 2025Review
- Ferritin Fused with MiniSOG forACS applied bio materials · 2025Article
- Design and application of ferritin-based nanomedicine for targeted cancer therapy.Nanomedicine (London, England) · 2025Review
- Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging.Nature communications · 2025Article
- Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker.Current issues in molecular biology · 2025Review
- Bioactive Molecules Delivery through Ferritin Nanoparticles: Sum Up of Current Loading Methods.Molecules (Basel, Switzerland) · 2024Review
- Self-Assembly of Heterogeneous Ferritin Nanocages for Tumor Uptake and Penetration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Ferritin-nanocaged aggregation-induced emission nanoaggregates for NIR-II fluorescence-guided noninvasive, controllable male contraception.Materials today. Bio · 2024Article
- Serum ferritin level is an effective prognostic factor for lung cancer immunotherapy.Cancer biology & therapy · 2023Article
- Carbon Dots: Opportunities and Challenges in Cancer Therapy.Pharmaceutics · 2023Review
- Ferritin-based nanomedicine for disease treatment.Medical review (2021) · 2023Review
- Magnetosome-inspired synthesis of soft ferrimagnetic nanoparticles for magnetic tumor targeting.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Ferritin - a multifaceted protein scaffold for biotherapeutics.Experimental & molecular medicine · 2022Review
- Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics: Underlying risks and the emergence of ultrasmall nanomagnets.Journal of pharmaceutical analysis · 2022Review
- The Impact of Redox, Hydrolysis and Dehydration Chemistry on the Structural and Magnetic Properties of Magnetoferritin Prepared in Variable Thermal Conditions.Molecules (Basel, Switzerland) · 2021Article
- Cargo loading within ferritin nanocages in preparation for tumor-targeted delivery.Nature protocols · 2021Review
- Nanoconjugates to enhance PDT-mediated cancer immunotherapy by targeting the indoleamine-2,3-dioxygenase pathway.Journal of nanobiotechnology · 2021Article
- Nanotechnological Applications Based on Bacterial Encapsulins.Nanomaterials (Basel, Switzerland) · 2021Review
- Peripherally Crowded Cationic Phthalocyanines as Efficient Photosensitizers for Photodynamic Therapy.ACS medicinal chemistry letters · 2021Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Photodynamic therapy is an emerging treatment modality that is under intensive preclinical and clinical investigations for many types of disease including cancer. Despite the promise, there is a lack of a reliable drug delivery vehicle that can transport photosensitizers (PSs) to tumors in a site-specific manner. Previous efforts have been focused on polymer- or liposome-based nanocarriers, which are usually associated with a suboptimal PS loading rate and a large particle size. We report herein that a RGD4C-modified ferritin (RFRT), a protein-based nanoparticle, can serve as a safe and efficient PS vehicle. Zinc hexadecafluorophthalocyanine (ZnF16Pc), a potent PS with a high (1)O2 quantum yield but poor water solubility, can be encapsulated into RFRTs with a loading rate as high as ~60 wt % (i.e., 1.5 mg of ZnF16Pc can be loaded on 1 mg of RFRTs), which far exceeds those reported previously. Despite the high loading, the ZnF16Pc-loaded RFRTs (P-RFRTs) show an overall particle size of 18.6 ± 2.6 nm, which is significantly smaller than other PS-nanocarrier conjugates. When tested on U87MG subcutaneous tumor models, P-RFRTs showed a high tumor accumulation rate (tumor-to-normal tissue ratio of 26.82 ± 4.07 at 24 h), a good tumor inhibition rate (83.64% on day 12), as well as minimal toxicity to the skin and other major organs. This technology can be extended to deliver other metal-containing PSs and holds great clinical translation potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.