ArticleJournal of the American Chemical Society2013
A dual Lewis base activation strategy for enantioselective carbene-catalyzed annulations.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 333 citations in OpenAlex.
- dThe journal of physical chemistry letters · 2025Article
- Chiral Lewis Base-Catalysed Asymmetric Syntheses of Benzo-fused ϵ-Lactones.European journal of organic chemistry · 2023Article
- Dynamic kinetic resolution of γ,γ-disubstituted indole 2-carboxaldehydesChemical science · 2022Article
- Recent advances of N-heterocyclic carbenes in the applications of constructing carbo- and heterocyclic frameworks with potential biological activity.RSC advances · 2021Review
- Synthetic Studies of the Rubellin Natural Products: Development of a Stereoselective Strategy and Total Synthesis of (+)-Rubellin C.The Journal of organic chemistry · 2021Article
- Bifunctional reagents in organic synthesis.Nature reviews. Chemistry · 2021Review
- Enantioselective one-pot synthesis of 4RSC advances · 2020Article
- Diastereoselective synthesis of CFRSC advances · 2020Article
- Cooperative Catalysis for the Highly Diastereo- and Enantioselective [4+3]-Cycloannulation of ortho-Quinone Methides and Carbonyl Ylides.Angewandte Chemie (International ed. in English) · 2020Article
- New Developments of the Principle of Vinylogy as Applied to π-Extended Enolate-Type Donor Systems.Chemical reviews · 2020Article
- Mechanism and stereoselectivity in NHC-catalyzed β-functionalization of saturated carboxylic ester.RSC advances · 2019Article
- Enantioselective Phenolic α-Oxidation Using HJournal of the American Chemical Society · 2019Article
- Article
- Redox-triggered cascade dearomative cyclizations enabled by hexafluoroisopropanol.Chemical science · 2018Article
- Formal (4 + 1)-Addition of Allenoates to o-Quinone Methides.Organic letters · 2018Article
- N-Heterocyclic carbene-catalyzed oxidative [3 + 2] annulation of dioxindoles and enals: cross coupling of homoenolate and enolate.Chemical science · 2017Article
- N-Heterocyclic Carbene and Chiral Brønsted Acid Cooperative Catalysis for a Highly Enantioselective [4+2] Annulation.Synthesis · 2017Article
- Palladium-Catalyzed Enantioselective Redox-Relay Heck Arylation of 1,1-Disubstituted Homoallylic Alcohols.Journal of the American Chemical Society · 2016Article
- Copper-Catalyzed Borylative Aromatization ofACS catalysis · 2016Article
- Switchable selectivity in an NHC-catalysed dearomatizing annulation reaction.Nature chemistry · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A dual activation strategy integrating N-heterocyclic carbene (NHC) catalysis and a second Lewis base has been developed. NHC-bound homoenolate equivalents derived from α,β-unsaturated aldehydes combine with transient reactive o-quinone methides in an enantioselective formal [4 + 3] fashion to access 2-benzoxopinones. The overall approach provides a general blueprint for the integration of carbene catalysis with additional Lewis base activation modes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.