ArticleAmerican journal of hematology2013
Multiplicative interaction between mean corpuscular volume and red cell distribution width in predicting mortality of elderly patients with and without anemia.
Article in American journal of hematology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Prognostic Value of Red Blood Cell Distribution Width in Non-Cardiovascular Critically or Acutely Patients: A Systematic Review.PloS one · 2016Pooled it
- Early postoperative red cell distribution width is associated with prolonged hospital stay and complications after non-cardiac surgery in neonates.International journal of medical sciences · 2026Article
- Significance of preoperative mean corpuscular volume in patients with stage II/III colorectal cancer and anemia.International journal of clinical oncology · 2025Article
- The longevity factor spermidine is part of a highly heritable complex erythrocyte phenotype associated with longevity.Aging cell · 2024Article
- Alteration of clinical parameters before mortality and prognostic outcomes of pulmonary hypertension in dogs with myxomatous mitral valve disease.Open veterinary journal · 2024Article
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- Association of red blood cell distribution width with hospital admission and in-hospital mortality across all-cause adult emergency department visits.JAMIA open · 2023Article
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- A machine learning-based data mining in medical examination data: a biological features-based biological age prediction model.BMC bioinformatics · 2022Article
- A novel model forecasting perioperative red blood cell transfusion.Scientific reports · 2022Article
- Succinate dehydrogenase inversely regulates red cell distribution width and healthy life span in chronically hypoxic mice.JCI insight · 2022Article
- Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- A Machine Learning-Based Aging Measure Among Middle-Aged and Older Chinese Adults: The China Health and Retirement Longitudinal Study.Frontiers in medicine · 2021Article
- The prognostic value of interaction between mean corpuscular volume and red cell distribution width in mortality in chronic kidney disease.Scientific reports · 2018Article
- The mean corpuscular volume as a prognostic factor for colorectal cancer.Surgery today · 2018Article
- Multiplicative interaction between mean corpuscular volume and red cell distribution width with target organ damage in hypertensive patients.Journal of clinical laboratory analysis · 2017Article
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- Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia.Cancer research · 2016Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Recent studies have shown that an elevated red cell distribution width (RDW) is an important predictor of adverse outcomes. However, the strength of this biomarker has not been tested in a large outpatient elderly population. Also since increased RDW can be due to a variety of etiologies, additional biomarkers are needed to refine the prognostic value of this variable. We assembled a cohort of 36,226 elderly (≥65yo) patients seen at an outpatient facility within the Einstein/Montefiore system from January 1st 1997 to May 1st 2008 who also had a complete blood count performed within 3 months of the initial visit. With a maximum follow-up of 10 years, we found that an elevated RDW (>16.6) was associated with increased risk of mortality in both non-anemic (HR = 3.66, p < 0.05) and anemic patients (HR = 1.87, p < 0.05). The effect of RDW on mortality is significantly increased in non-anemic patients with macrocytosis (HR = 5.22, p < 0.05) compared to those with normocytosis (HR = 3.86, p < 0.05) and microcytosis (HR = 2.46, p < 0.05). When comparing non-anemic patients with both an elevated RDW and macrocytosis to those with neither, we observed an elevated HR of 7.76 (higher than expected in an additive model). This multiplicative interaction was not observed in anemic patients (HR = 2.23). Lastly, we constructed Kaplan-Meier curves for each RDW/MCV subgroup and found worsened survival for those with macrocytosis and an elevated RDW in both anemia and non-anemic patients. Based on our results, the addition of MCV appears to improve the prognostic value of RDW as a predictor of overall survival in elderly patients.
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