Evidence map›Paper›PMID 23828629›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2014

Synthesis of brightly PEGylated luminescent magnetic upconversion nanophosphors for deep tissue and dual MRI imaging.

Hongyu Chen, Bin Qi, Thomas Moore, Daniel C Colvin, Thomas Crawford, John C Gore, Frank Alexis, O Thompson Mefford, Jeffrey N Anker

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. LiGaMaterials horizons · 2017
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongyu ChenDepartment of Chemistry, Center for Optical Materials Science and Engineering (COMSET) and Environmental Toxicology Program, Clemson University, Clemson SC, 29634, USA.
Bin Qi
Thomas Moore
Daniel C Colvin
Thomas Crawford
John C Gore
Frank Alexis
O Thompson Mefford
Jeffrey N Anker

Funding

Targeted Nano-therapeutics for Neural RegenerationP20GM103444 · NIGMS · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R, VYAVAHARE, NAREN R · 2012 to 2018
$14.9M
UNDERSTANDING AND CONTROLLING TISSUE-SPECIFIC VASCULAR PATTERNINGP20RR021949 · NCRR · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R · 2009 to 2011
$5.2M
Investigating Mechanism of Intracellular Rotational Transport with Optical TR15EB014560 · NIBIB · CLEMSON UNIVERSITY · PI ANKER, JEFFREY N · 2012 to 2012
$216k
NCRR NIH HHS 5P20RR021949NCRR NIH HHS P20 RR021949NIBIB NIH HHS 1R15EB014560NIBIB NIH HHS R15 EB014560NIGMS NIH HHS 8P20GM103444NIGMS NIH HHS P20 GM103444
6 · The paper itself

Abstract

A method is developed to fabricate monodispersed biocompatible Yb/Er or Yb/Tm doped β-NaGdF4 upconversion phosphors using polyelectrolytes to prevent irreversible particle aggregation during conversion of the precursor, Gd2 O(CO3 )2.H2 O:Yb/Er or Yb/Tm, to β-NaGdF4 :Yb/Er or Yb/Tm. The polyelectrolyte on the outer surface of nanophosphors also provided an amine tag for PEGylation. This method is also employed to fabricate PEGylated magnetic upconversion phosphors with Fe3 O4 as the core and β-NaGdF4 as a shell. These magnetic upconversion nanophosphors have relatively high saturation magnetization (7.0 emu g(-1) ) and magnetic susceptibility (1.7 × 10(-2) emu g(-1) Oe(-1) ), providing them with large magnetophoretic mobilities. The magnetic properties for separation and controlled release in flow, their optical properties for cell labeling, deep tissue imaging, and their T1 - and T2 -weighted magnetic resonance imaging (MRI) relaxivities are studied. The magnetic upconversion phosphors display both strong magnetophoresis, dual MRI imaging (r1 = 2.9 mM(-1) s(-1) , r2 = 204 mM(-1) s(-1) ), and bright luminescence under 1 cm chicken breast tissue.

Indexed as

LuminescenceContrast MediaDiagnostic ImagingMagnetic Resonance ImagingNanoparticlesPolyethylene GlycolsContrast MediaPolyethylene Glycolscapture and releasedeep tissue imagingmagnetic nanoparticlesMRIupconversion nanophosphors

Identifiers

PMID23828629
PMCPMC4118939

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.