ArticleCell death & disease2013
The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity.
Article in Cell death & disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation.Molecular pharmacology · 2015Review
- The G protein-coupled receptor P2Y14 influences insulin release and smooth muscle function in mice.The Journal of biological chemistry · 2014Article
- Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence.The Journal of clinical investigation · 2014Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
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Abstract
In utero exposure of the embryo and fetus to radiation has been implicated in malformations or fetal death, and often produces lifelong health consequences such as cancers and mental retardation. Here we demonstrate that deletion of a G-protein-coupled purinergic receptor, P2Y14, confers potent resistance to in utero radiation. Intriguingly, a putative P2Y14 receptor ligand, UDP-glucose, phenocopies the effect of P2Y14 deficiency. These data indicate that P2Y14 is a receptor governing in utero tolerance to genotoxic stress that may be pharmacologically targeted to mitigate radiation toxicity in pregnancy.
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