ArticleLab on a chip2013
Microfluidic devices with permeable polymer barriers for capture and transport of biomolecules and cells.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Sliding walls: a new paradigm for fluidic actuation and protocol implementation in microfluidics.Microsystems & nanoengineering · 2020Article
- Partitioning of hydrogels in 3D-printed microchannels.Lab on a chip · 2019Article
- Ultraaccurate genome sequencing and haplotyping of single human cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A Microfluidic Platform Containing Sidewall Microgrooves for Cell Positioning and Trapping.NanobiomedicineArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We report a method for fabricating permeable polymer microstructure barriers in polydimethylsiloxane (PDMS) microfluidic devices and the use of the devices to capture and transport DNA and cells. The polymer microstructure in a desired location in a fluidic channel is formed in situ by the polymerization of acrylamide and polyethylene diacrylate cross-linker (PEG-DA) monomer in a solution which is trapped in the location using a pair of PDMS valves. The porous polymer microstructure provides a mechanical barrier to convective fluid flow in the channel or between two microfluidic chambers while it still conducts ions or small charged species under an electric field, allowing for the rapid capture and transport of biomolecules and cells by electrophoresis. We have demonstrated the application of the devices for the rapid capture and efficient release of bacteriophage λ genomic DNA, solution exchange and for the transport and capture of HeLa cells. Our devices will enable the multi-step processing of biomolecules and cells or individual cells within a single microfluidic chamber.
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Registered trials
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