Evidence map›Paper›PMID 23828493›Full record

Trial reportLasers in medical science2015

Adjunctive effect of antimicrobial photodynamic therapy to nonsurgical periodontal treatment in smokers: a randomized clinical trial.

Adriana C Queiroz, Flávia Adelino Suaid, Patrícia Freitas de Andrade, Fabíola S Oliveira, Arthur B Novaes, Mário Taba, Daniela B Palioto, Márcio F M Grisi, Sérgio L S Souza

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Lasers in medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Adriana C QueirozSchool of Dentistry, Federal University of Amazonas, Av. Valdemar Pedrosa, 1539, Manaus, Amazonas, Brazil.
Flávia Adelino Suaid
Patrícia Freitas de Andrade
Fabíola S Oliveira
Arthur B Novaes
Mário Taba
Daniela B Palioto
Márcio F M Grisi
Sérgio L S Souza
Universidade de São Paulo · BRUniversidade Federal do Amazonas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the adjunctive effect of antimicrobial photodynamic therapy (aPDT) to scaling and root planing (SRP) in smokers with chronic periodontitis. Twenty subjects had two contralateral teeth randomly assigned to receive SRP (SRP group) or SRP + a single episode of aPDT (SRP + aPDT group), with a diode laser and a phenothiazine photosensitizer. Plaque index, bleeding on probing, probing depth (PD), clinical attachment level (CAL), and gingival recession were recorded, and gingival crevicular fluid was collected for assay of IL-1β and matrix metalloproteinase (MMP)-8 levels. There was a significant PD reduction (SRP 1.81 ± 0.52 mm/SRP + aPDT 1.58 ± 1.28 mm; p < 0.001) and a significant CAL gain (SRP 1.60 ± 0.92 mm/SRP + aPDT 1.41 ± 1.58 mm; p < 0.001) for both groups. Significant differences were not observed in between-group comparisons. IL-1β level in gingival crevicular fluid was higher in SRP group after 1 week (SRP 24.65 ± 18.85 pg/μL/SRP + aPDT 34.07 ± 24.81 pg/μL; p = 0.048), and MMP-8 level was higher in SRP group after 12 weeks (SRP 303.31 ± 331.62 pg/μL/SRP + aPDT 534.23 ± 647.37 pg/μL; p = 0.024). There were no statistically significant differences in intragroup comparisons. The adjunctive effect of aPDT did not warrant improvements on clinical parameters in smokers. However, it resulted in a suppression of IL-1β and MMP-8 when compared with SRP alone.

Indexed as

AdultAnti-Infective AgentsChronic PeriodontitisCombined Modality TherapyDental Plaque IndexDental ScalingFemaleGingival Crevicular FluidGingival RecessionHumansInterleukin-1betaLasers, SemiconductorMaleMatrix Metalloproteinase 8Middle AgedPeriodontitisAnti-Infective AgentsIL1B protein, humanInterleukin-1betaMatrix Metalloproteinase 8MMP8 protein, humanPhotosensitizing Agents

Identifiers

PMID23828493
OpenAlexW2031105985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.