ArticleLab on a chip2013
A microfluidic approach for protein structure determination at room temperature via on-chip anomalous diffraction.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Technical Scale in Biomolecular Crystallization.Advances in biochemical engineering/biotechnology · 2026Review
- Microfluidic Devices for High-Throughput In Situ Serial Crystallography.Advances in biochemical engineering/biotechnology · 2026Review
- Scalable fabrication of an array-type fixed-target device for automated room temperature X-ray protein crystallography.Scientific reports · 2025Article
- JINXED: just in time crystallization for easy structure determination of biological macromolecules.IUCrJ · 2023Article
- Polymer-based microfluidic device for on-chip counter-diffusive crystallization andLab on a chip · 2023Article
- A capillary-based microfluidic device enables primary high-throughput room-temperature crystallographic screening.Journal of applied crystallography · 2021Article
- Microfluidic Protein Imaging Platform: Study of Tau Protein Aggregation and Alzheimer's Drug Response.Bioengineering (Basel, Switzerland) · 2020Article
- An automated platform forIUCrJ · 2020Article
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- Sample delivery for serial crystallography at free-electron lasers and synchrotrons.Acta crystallographica. Section D, Structural biology · 2019Review
- Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography.Journal of visualized experiments : JoVE · 2018Article
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- Graphene-based microfluidics for serial crystallography.Lab on a chip · 2016Article
- In situ X-ray data collection and structure phasing of protein crystals at Structural Biology Center 19-ID.Journal of synchrotron radiation · 2015Article
- Fabrication of Microfluidic Valves Using a Hydrogel Molding Method.Scientific reports · 2015Article
- Towards time-resolved serial crystallography in a microfluidic device.Acta crystallographica. Section F, Structural biology communications · 2015Article
- Capture and X-ray diffraction studies of protein microcrystals in a microfluidic trap array.Acta crystallographica. Section D, Biological crystallography · 2015Article
- Article
- X-ray Transparent Microfluidic Chip for Mesophase-Based Crystallization of Membrane Proteins and On-Chip Structure Determination.Crystal growth & design · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We report a microfluidic approach for de novo protein structure determination via crystallization screening and optimization, as well as on-chip X-ray diffraction data collection. The structure of phosphonoacetate hydrolase (PhnA) has been solved to 2.11 Åvia on-chip collection of anomalous data that has an order of magnitude lower mosaicity than what is typical for traditional structure determination methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.