Trial reportMedical science monitor : international medical journal of experimental and clinical research2013
Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis.
Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Clinical and endocrine effects of pharmacological therapy in endometriosis: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Is Scientific Medical Literature Related to Endometriosis Treatment Evidence-Based? A Systematic Review on Methodological Quality of Randomized Clinical Trials.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Statin therapy decreased the recurrence frequency of atrial fibrillation after electrical cardioversion: a meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2014Pooled it
- Effect of simvastatin on monocyte chemoattractant protein-1 expression in endometriosis patients: a randomized controlled trial.BMC women's health · 2017Trial
- Effects of Vitamin D on Endometriosis-Related Pain: A Double-Blind Clinical Trial.Medical science monitor : international medical journal of experimental and clinical research · 2016Trial
- Efficacy and safety investigation of Kuntai capsule for the add-back therapy of gonadotropin releasing hormone agonist administration to endometriosis patients: a randomized, double-blind, blank- and tibolone-controlled study.Chinese medical journal · 2015Trial
- Efficacy and safety of remifemin on peri-menopausal symptoms induced by post-operative GnRH-a therapy for endometriosis: a randomized study versus tibolone.Medical science monitor : international medical journal of experimental and clinical research · 2014Trial
- Article
- Closing the evidence loop-membrane-lipid homeostasis and vesicular transport link DEHP exposure to endometriosis.Human genomics · 2025Article
- Integrative bioinformatics analysis of lipid metabolism-related genes and immune infiltration in endometriosis.Medicine · 2025Article
- Article
- Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis.Microvascular research · 2022Article
- New therapeutic approaches for endometriosis besides hormonal therapy.Chinese medical journal · 2019Review
- Beneficial Effects of Oral Lactobacillus on Pain Severity in Women Suffering from Endometriosis: A Pilot Placebo-Controlled Randomized Clinical Trial.International journal of fertility & sterility · 2019Article
- Serum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Molecular Targets for Endometriosis Therapy: Where We Are and Where We Are Going?International journal of fertility & sterility · 2019Article
- Lipophilic statins inhibit growth and reduce invasiveness of human endometrial stromal cells.Journal of assisted reproduction and genetics · 2019Article
- Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies.International journal of molecular sciences · 2018Review
- Effect of simvastatin on baboon endometriosis.Biology of reproduction · 2017Article
- Simvastatin versus triptorelin in prevention of pain recurrences after surgery for endometriosis.Medical science monitor : international medical journal of experimental and clinical research · 2013Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis. MATERIAL/
methodsSixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses.
resultsUsing VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05).
conclusionsBoth treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.