ArticlePharmacology, biochemistry, and behavior2013
Oxycodone-induced conditioned place preference and sensitization of locomotor activity in adolescent and adult mice.
Article in Pharmacology, biochemistry, and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 57 citations in OpenAlex.
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- Examining the impact of adolescent social isolation on oxycodone sensitization.Psychopharmacology · 2026Article
- Differential acquisition of cocaine and heroin self-administration in a rat model of internalizing versus externalizing temperament.bioRxiv : the preprint server for biology · 2026Article
- A mouse model of oxycodone reward following its oral self-administration in a sweetened solution.Frontiers in behavioral neuroscience · 2026Article
- Pharmacological and genetic manipulation of glyoxalase-1 (GLO1) does not alter locomotor responses or conditioned place preference induced by cocaine or oxycodone.Pharmacology, biochemistry, and behavior · 2025Article
- Interactions of pain and opioids on conditioned place preference in rodents.Psychopharmacology · 2025Review
- Effects of novel beta-lactam, MC-100093, and ceftriaxone on astrocytic glutamate transporters and neuroinflammatory factors in nucleus accumbens of C57BL/6 mice exposed to escalated doses of morphine.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats.Scientific reports · 2023Article
- An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats.Research square · 2023Article
- Oxycodone, an opioid like the others?Frontiers in psychiatry · 2023Review
- Oral oxycodone self-administration leads to features of opioid misuse in male and female mice.Addiction biology · 2023Article
- Sex-specific role for serotonin 5-HTNeuropharmacology · 2022Article
- Sex-dependent impact of microbiota status on cerebral μ-opioid receptor density in fischer rats.The European journal of neuroscience · 2022Review
- A limited access oral oxycodone paradigm produces physical dependence and mesocorticolimbic region-dependent increases in DeltaFosB expression without preference.Neuropharmacology · 2022Article
- Anterior cingulate cortex and its projections to the ventral tegmental area regulate opioid withdrawal, the formation of opioid context associations and context-induced drug seeking.Frontiers in neuroscience · 2022Article
- Effects of fentanyl on acute locomotor activity, behavioral sensitization, and contextual reward in female and male rats.Drug and alcohol dependence · 2021Article
- Melatonin attenuates morphine-induced conditioned place preference in Wistar rats.Brain and behavior · 2021Article
- Adolescent oxycodone exposure inhibits withdrawal-induced expression of genes associated with the dopamine transmission.Addiction biology · 2021Article
- Mu opioid receptors on vGluT2-expressing glutamatergic neurons modulate opioid reward.Addiction biology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nonmedical use of the prescription opioid oxycodone has become a major public health problem in the United States, with special concern for adolescents. Although adults and adolescents have different sensitivities for drugs, little is known about the rewarding effects of oxycodone in adolescents compared to adults, even in rodent models. Here, we investigate sensitivity to oxycodone by the conditioned place preference assay of conditioned reward, and effect on the locomotor activity in adolescent (4 weeks old) and adult (10 weeks old) C57BL/6J mice. Mice of both ages were trained with multiple doses of oxycodone (0, 0.3, 1, and 3 mg/kg) and showed conditioned preference in a dose-dependent manner. The adult mice developed conditioned preference to the lowest dose tested (0.3 mg/kg), but adolescent mice did not. Dose-dependent oxycodone-induced increases in locomotor activity were observed across the conditioning session. Interestingly, adolescent mice developed greater sensitization to the locomotor-activating effects of oxycodone than adult mice. Thus differences in sensitivity to oxycodone, such as the lower initial sensitivity for conditioned preference but greater locomotor sensitization in adolescent mice, may indicate contributing factors in oxycodone abuse and later addiction in human adolescents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.