ArticleBrain research2013
Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish.
Article in Brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 86 citations in OpenAlex.
- ZembrinMolecules (Basel, Switzerland) · 2026Article
- Dioxopiperidinamide Derivative SKT-36 Alleviates scopolamine-induced Cognitive and Neurobehavioral Impairments in an In-vivo Zebrafish Model.Cell biochemistry and biophysics · 2026Article
- Behavioral Alterations in Male Zebrafish After Administration of Androgen Receptor Blockers and an Activator.Biology · 2026Article
- Efficacy of Probiotic Escherichia coli Nissle 1917 in Counteracting Reserpine-induced Depression-like Symptoms and Neuroinflammation in Zebrafish.Indian journal of psychological medicine · 2026Article
- Systematic analysis of proximal midgut- and anorectal-originating contractions in larval zebrafish using event feature detection and supervised machine learning algorithms.Neurogastroenterology and motility · 2023Article
- A Mini-Review Regarding the Modalities to Study Neurodevelopmental Disorders-Like Impairments in Zebrafish-Focussing on Neurobehavioural and Psychological Responses.Brain sciences · 2022Review
- Influence of Incorporation of Different dInternational journal of molecular sciences · 2021Article
- A Reliable High-Throughput Screening Model for Antidepressant.International journal of molecular sciences · 2021Article
- Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential.Life (Basel, Switzerland) · 2021Review
- Clitorienolactones and Isoflavonoids ofMolecules (Basel, Switzerland) · 2021Article
- Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours?Molecular neurobiology · 2021Article
- A Zebrafish Model of Neurotoxicity by Binge-Like Methamphetamine Exposure.Frontiers in pharmacology · 2021Article
- Review on the occurrence and biological effects of illicit drugs in aquatic ecosystems.Environmental science and pollution research international · 2020Review
- Article
- The psychoactive cathinone derivative pyrovalerone alters locomotor activity and decreases dopamine receptor expression in zebrafish (Danio rerio).Brain and behavior · 2019Article
- Automatic multiple zebrafish tracking based on improved HOG features.Scientific reports · 2018Article
- Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM).Behavioral and brain functions : BBF · 2018Article
- Acrylamide acute neurotoxicity in adult zebrafish.Scientific reports · 2018Article
- Adult zebrafish in CNS disease modeling: a tank that's half-full, not half-empty, and still filling.Lab animal · 2017Article
- Zebrafish models in neuropsychopharmacology and CNS drug discovery.British journal of pharmacology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Brain monoamines play a key role in the regulation of behavior. Reserpine depletes monoamines, and causes depression and hypoactivity in humans and rodents. In contrast, d-amphetamine increases brain monoamines' levels, and evokes hyperactivity and anxiety. However, the effects of these agents on behavior and in relation to monoamine levels remain poorly understood, necessitating further experimental studies to understand their psychotropic action. Zebrafish (Danio rerio) are rapidly emerging as a promising model organism for drug screening and translational neuroscience research. Here, we have examined the acute and long-term effects of reserpine and d-amphetamine on zebrafish behavior in the novel tank test. Overall, d-amphetamine (5 and 10mg/L) evokes anxiogenic-like effects in zebrafish acutely, but not 7 days later. In contrast, reserpine (20 and 40 mg/L) did not evoke overt acute behavioral effects, but markedly reduced activity 7 days later, resembling motor retardation observed in depression and/or Parkinson's disease. Three-dimensional 'temporal' (X, Y, time) reconstructions of zebrafish locomotion further supports these findings, confirming the utility of 3D-based video-tracking analyses in zebrafish models of drug action. Our results show that zebrafish are highly sensitive to drugs bi-directionally modulating brain monoamines, generally paralleling rodent and clinical findings. Collectively, this emphasizes the potential of zebrafish tests to model complex brain disorders associated with monoamine dysregulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.