ArticleVeterinary microbiology2013
Pathogenicity of porcine G9P[23] and G9P[7] rotaviruses in piglets.
Article in Veterinary microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Whole-genome characterization and pathogenicity of novel human-porcine reassortant rotavirus strains G9P[7] and G1P[7] in China.Veterinary research · 2026Article
- Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus.Virologica Sinica · 2026Article
- The efficiency of rotavirus A spread to extraintestinal tissues is not determined by the levels of its replication in the gut.PLoS pathogens · 2025Article
- Rotavirus Reverse Genetics Systems and Oral Vaccine Delivery Vectors for Mucosal Vaccination.Microorganisms · 2025Review
- Isolation and possibility of vertical transmission of G9P[23] and G12P[7] group A rotavirus strains in pigs.Porcine health management · 2025Article
- Phylogenitc analysis and immunogenicity comparison of porcine genotype G9 rotavirus in China from 2020-2023.Virologica Sinica · 2025Article
- High pathogenicity of emerging porcine G9P[23] and G11P[7] rotavirus for newborn piglets in China.Frontiers in veterinary science · 2025Article
- Isolation and Genomic Characterization of the G6P[1]-Type Sheep Rotavirus in China.Transboundary and emerging diseases · 2024Article
- Article
- Commentary: Identification of pulmonary infections with porcine Rotavirus A in pigs with respiratory disease.Frontiers in veterinary science · 2023Article
- Identification of Pulmonary Infections With Porcine Rotavirus A in Pigs With Respiratory Disease.Frontiers in veterinary science · 2022Article
- Development of a live attenuated trivalent porcine rotavirus A vaccine against disease caused by recent strains most prevalent in South Korea.Veterinary research · 2019Article
- The dynamics of a Chinese porcine G9P[23] rotavirus production in MA-104 cells and intestines of 3-day-old piglets.The Journal of veterinary medical science · 2018Article
- Comparative In Vitro and In Vivo Studies of Porcine Rotavirus G9P[13] and Human Rotavirus Wa G1P[8].Journal of virology · 2016Article
- Evidences and consequences of extra-intestinal spread of rotaviruses in humans and animals.Virusdisease · 2014Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G9 group A rotaviruses (RVAs) are considered important pathogens in pigs and humans, and pigs are hypothesized to be a potential host reservoir for human. However, intestinal and extra-intestinal pathogenicity and viremia of porcine G9 RVAs has remained largely unreported. In this study, colostrum-deprived piglets were orally infected with a porcine G9P[23] or G9P[7] strain. Histopathologically, both strains induced characteristic small intestinal lesions. Degeneration and necrosis of parenchymal cells were observed in the extra-intestinal tissues, but most predominantly in the mesenteric lymph nodes (MLNs). RVA antigen was continuously detected in the small intestinal mucosa and MLNs, but only transiently in cells of the liver, lung, and choroid plexus. Viral RNA levels were much higher in the feces and the MLNs compared to other tissues. The onset of viremia occurred at day post infection (DPI) 1 with the amount of viral RNA reaching its peak at DPI 3 or 5, before decreasing significantly at DPI 7 and remaining detectable until DPI 14. Our data suggest that porcine G9 RVAs have a strong small intestinal tropism, are highly virulent for piglets, have the ability to escape the small intestine, spread systemically via viremia, and replicate in extra-intestinal tissues. In addition, MLNs might act as a secondary site for viral amplification and the portal of systemic entry. These results add to our understanding of the pathogenesis of human G9 RVAs, and the validity of the pig model for use with both human and pig G9 RVAs in further studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.