ArticleBMC endocrine disorders2013
Decreased levels of physical activity in adolescents with down syndrome are related with low bone mineral density: a cross-sectional study.
Article in BMC endocrine disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Genome-wide cell type-specific and sex-specific transcriptional dysregulation in the islet of Langerhans underlies islet dysfunction in Down syndrome-related diabetes.bioRxiv : the preprint server for biology · 2026Article
- Some Biomechanical and Anthropmetric Differences Between Elite Swimmers with Down Syndrome and Intellectual Disabilities.Sports (Basel, Switzerland) · 2026Article
- Technology Utilisation and Engagement in Physical Activity of Adolescents With Intellectual Disabilities: A Scoping Review.Journal of applied research in intellectual disabilities : JARID · 2026Article
- Article
- The aetiology of atypical bone health in individuals with Down syndrome.Archives of osteoporosis · 2023Review
- Article
- The Amount of Light to Vigorous Physical Activity (Met's-Hours/Day) in Children with and without Down Syndrome Attending Elementary School in Japan.International journal of environmental research and public health · 2023Article
- Current Analysis of Skeletal Phenotypes in Down Syndrome.Current osteoporosis reports · 2021Review
- Article
- Review
- Atlantoaxial dislocation due to os odontoideum in patients with Down's syndrome: literature review and case reports.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- Association between Physical Activity and Adiposity in Adolescents with Down Syndrome.Medicine and science in sports and exercise · 2018Article
- Diverging results of areal and volumetric bone mineral density in Down syndrome.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Determinants of vitamin d levels in children and adolescents with down syndrome.International journal of endocrinology · 2015Article
- Obesity Prevention for Children with Developmental Disabilities.Current obesity reports · 2014Article
- Health promotion and disease prevention strategies in older adults with intellectual and developmental disabilities.Frontiers in public health · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDown syndrome (DS) has been described as one of the main contributors for low bone mineral density (BMD). Physical activity (PA) is a key factor in skeletal health and thus, PA levels might be associated to the risk of developing osteoporosis. Therefore, the aims were (1) to describe PA patterns in adolescents with DS compared to their counterparts and (2) to determine the relationships between PA and the risk of having low bone mass in adolescents with DS.
methodsNineteen adolescents (10 girls) with DS and 14 without disabilities (7 girls) participated in the study. Minutes in different PA intensities were objectively assessed with accelerometers (ActiTrainer). Moreover adolescents with DS were classified into PA tertiles taking into account the amount of total minutes of PA at any intensity, resulting in those performing low, medium or high of PA (lowPA, medPA and highPA). BMD was measured at the whole body, hip and lumbar spine with dual-energy X-ray absorptiometry and the BMD Z-score was calculated for each region taking into account age- and sex-matched reference data. Student's unpaired t-tests and analysis of covariance were used to compare variables between different conditions (DS vs. control) and PA levels (low, medium and high).
resultsNone of the adolescents with DS achieved the minimum of 60 min of daily moderate to vigorous PA (VPA) intensity recommended by PA guidelines; adolescents with DS group spent less time in sedentary and in VPA and more time in light PA than those without DS (p < 0.05). Adolescents with DS showed lower BMD Z-score values than those without (p < 0.05). Those adolescents with DS allocated in the lowPA tertile showed significant lower BMD Z-score at the hip and a general tendency towards lower BMD Z-score was found at whole body and lumbar spine compared to those in highPA tertile and (p < 0.05).
conclusionsAdolescents with DS in the highPA tertile showed lower risk of developing future osteoporosis by having higher BMD Z-score at the hip. This data provides an idea regarding the importance of accumulated minutes of PA, and not only moderate or vigorous in the bone health in adolescents with DS.
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