Evidence map›Paper›PMID 23826744›Full record

ArticleJournal of biological dynamics2013

A novel statistical analysis and interpretation of flow cytometry data.

H T Banks, D F Kapraun, W Clayton Thompson, Cristina Peligero, Jordi Argilaguet, Andreas Meyerhans

Open access · goldAbstract read
In one paragraph

Article in Journal of biological dynamics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

H T BanksCenter for Research in Scientific Computation and Center for Quantitative Sciences in Biomedicine, North Carolina State University, Raleigh, NC 27695-8212, USA. htbanks@ncsu.edu
D F Kapraun
W Clayton Thompson
Cristina Peligero
Jordi Argilaguet
Andreas Meyerhans
North Carolina State University · USPompeu Fabra University · ESInstitució Catalana de Recerca i Estudis Avançats · ES

Funding

Mathematical and Statistical Modeling to Inform Design of HIV Clinical TrialsR01AI071915 · NIAID · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI BANKS, H. THOMAS · 2006 to 2012
$4.6M
NIAID NIH HHS R01 AI071915NIAID NIH HHS R01AI071915-10
6 · The paper itself

Abstract

A recently developed class of models incorporating the cyton model of population generation structure into a conservation-based model of intracellular label dynamics is reviewed. Statistical aspects of the data collection process are quantified and incorporated into a parameter estimation scheme. This scheme is then applied to experimental data for PHA-stimulated CD4+T and CD8+T cells collected from two healthy donors. This novel mathematical and statistical framework is shown to form the basis for accurate, meaningful analysis of cellular behaviour for a population of cells labelled with the dye carboxyfluorescein succinimidyl ester and stimulated to divide.

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell ProliferationData Interpretation, StatisticalFlow CytometryFluoresceinsFluorescent DyesHumansMathematical ConceptsMitogensModels, ImmunologicalModels, StatisticalPhytohemagglutininsSuccinimides5-(6)-carboxyfluorescein diacetate succinimidyl esterFluoresceinsFluorescent DyesMitogensPhytohemagglutininsSuccinimides

Identifiers

PMID23826744
PMCPMC3753657
OpenAlexW2148035653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.